Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators

Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeting splicing modulators and BCLxL inhibition induce...

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Autores principales: Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson, Ping Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e8
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spelling oai:doaj.org-article:3d3b4213a3e7400997cdfc63d11b14e82021-12-02T15:35:02ZSensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators10.1038/s41467-018-08150-52041-1723https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e82019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08150-5https://doaj.org/toc/2041-1723Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeting splicing modulators and BCLxL inhibition induces synergistic cytotoxicity in cancer cells.Daniel AirdTeng TengChia-Ling HuangErmira PazolliDeepti BankaKahlin Cheung-OngCheryl EifertCraig FurmanZhenhua Jeremy WuMichael SeilerSilvia BuonamiciPeter FekkesCraig KarrJames PalacinoEunice ParkPeter G. SmithLihua YuYoshiharu MizuiMarkus WarmuthAgustin ChicasLaura CorsonPing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daniel Aird
Teng Teng
Chia-Ling Huang
Ermira Pazolli
Deepti Banka
Kahlin Cheung-Ong
Cheryl Eifert
Craig Furman
Zhenhua Jeremy Wu
Michael Seiler
Silvia Buonamici
Peter Fekkes
Craig Karr
James Palacino
Eunice Park
Peter G. Smith
Lihua Yu
Yoshiharu Mizui
Markus Warmuth
Agustin Chicas
Laura Corson
Ping Zhu
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
description Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeting splicing modulators and BCLxL inhibition induces synergistic cytotoxicity in cancer cells.
format article
author Daniel Aird
Teng Teng
Chia-Ling Huang
Ermira Pazolli
Deepti Banka
Kahlin Cheung-Ong
Cheryl Eifert
Craig Furman
Zhenhua Jeremy Wu
Michael Seiler
Silvia Buonamici
Peter Fekkes
Craig Karr
James Palacino
Eunice Park
Peter G. Smith
Lihua Yu
Yoshiharu Mizui
Markus Warmuth
Agustin Chicas
Laura Corson
Ping Zhu
author_facet Daniel Aird
Teng Teng
Chia-Ling Huang
Ermira Pazolli
Deepti Banka
Kahlin Cheung-Ong
Cheryl Eifert
Craig Furman
Zhenhua Jeremy Wu
Michael Seiler
Silvia Buonamici
Peter Fekkes
Craig Karr
James Palacino
Eunice Park
Peter G. Smith
Lihua Yu
Yoshiharu Mizui
Markus Warmuth
Agustin Chicas
Laura Corson
Ping Zhu
author_sort Daniel Aird
title Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
title_short Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
title_full Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
title_fullStr Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
title_full_unstemmed Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
title_sort sensitivity to splicing modulation of bcl2 family genes defines cancer therapeutic strategies for splicing modulators
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e8
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