Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India

INTRODUCTION: Transmission of dengue by transfusion of blood products has been documented, although the frequency of these occurrences and the level of viremia required to cause clinical dengue are unknown. The primary objective was to assess the prevalence of dengue NS1 antigen among healthy blood...

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Autores principales:	Remi Remakanth, Abhishekh Basavarajegowda, Rahul Dhodapkar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	blood donors ns1 antigenemia southern india Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/3d3c4993e49b478fb124d8a17bbe4c61
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spelling	oai:doaj.org-article:3d3c4993e49b478fb124d8a17bbe4c612021-11-12T10:08:28ZPrevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India0973-62471998-356510.4103/ajts.ajts_51_21https://doaj.org/article/3d3c4993e49b478fb124d8a17bbe4c612021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=140;epage=145;aulast=Remakanthhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565INTRODUCTION: Transmission of dengue by transfusion of blood products has been documented, although the frequency of these occurrences and the level of viremia required to cause clinical dengue are unknown. The primary objective was to assess the prevalence of dengue NS1 antigen among healthy blood donors at our blood center.METHODOLOGY: This was a cross-sectional study conducted in the Department of Transfusion Medicine, a tertiary care hospital in South-eastern India, from February 2019 to January 2020. A total of 968 donor samples were included in the study. Dengue NS1 antigen detection was done using enzyme-linked immunosorbent assay. Data regarding clinical, epidemiological, and demographic characteristics were collected from the donor questionnaire and records.RESULTS: In the study, the overall prevalence of Dengue NS1 antigen was 0.9%, with nine positive samples among the 968 samples tested. Eight of them were male, and 1 was a female donor. All of them were in the age group <32 years. Half of the positive donors were detected during December-January, the immediate post rainy season in this part of the country. Two-third of the positive donors were from rural areas.CONCLUSION: This study with a 0.9% throws light on the seroepidemiological prevalence of dengue among asymptomatic donors and gives an insight into whether dengue screening is required to be implemented in routine transfusion transmissible infection screening in blood transfusion services and shall assist in devising strategies to be adapted as to improve the blood safety.Remi RemakanthAbhishekh BasavarajegowdaRahul DhodapkarWolters Kluwer Medknow Publicationsarticleblood donorsns1 antigenemiasouthern indiaDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 140-145 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood donors ns1 antigenemia southern india Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	blood donors ns1 antigenemia southern india Diseases of the blood and blood-forming organs RC633-647.5 Remi Remakanth Abhishekh Basavarajegowda Rahul Dhodapkar Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
description	INTRODUCTION: Transmission of dengue by transfusion of blood products has been documented, although the frequency of these occurrences and the level of viremia required to cause clinical dengue are unknown. The primary objective was to assess the prevalence of dengue NS1 antigen among healthy blood donors at our blood center.METHODOLOGY: This was a cross-sectional study conducted in the Department of Transfusion Medicine, a tertiary care hospital in South-eastern India, from February 2019 to January 2020. A total of 968 donor samples were included in the study. Dengue NS1 antigen detection was done using enzyme-linked immunosorbent assay. Data regarding clinical, epidemiological, and demographic characteristics were collected from the donor questionnaire and records.RESULTS: In the study, the overall prevalence of Dengue NS1 antigen was 0.9%, with nine positive samples among the 968 samples tested. Eight of them were male, and 1 was a female donor. All of them were in the age group <32 years. Half of the positive donors were detected during December-January, the immediate post rainy season in this part of the country. Two-third of the positive donors were from rural areas.CONCLUSION: This study with a 0.9% throws light on the seroepidemiological prevalence of dengue among asymptomatic donors and gives an insight into whether dengue screening is required to be implemented in routine transfusion transmissible infection screening in blood transfusion services and shall assist in devising strategies to be adapted as to improve the blood safety.
format	article
author	Remi Remakanth Abhishekh Basavarajegowda Rahul Dhodapkar
author_facet	Remi Remakanth Abhishekh Basavarajegowda Rahul Dhodapkar
author_sort	Remi Remakanth
title	Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
title_short	Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
title_full	Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
title_fullStr	Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
title_full_unstemmed	Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India
title_sort	prevalence of dengue ns1 antigenemia among healthy blood donors in a tertiary care hospital in southern india
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/3d3c4993e49b478fb124d8a17bbe4c61
work_keys_str_mv	AT remiremakanth prevalenceofdenguens1antigenemiaamonghealthyblooddonorsinatertiarycarehospitalinsouthernindia AT abhishekhbasavarajegowda prevalenceofdenguens1antigenemiaamonghealthyblooddonorsinatertiarycarehospitalinsouthernindia AT rahuldhodapkar prevalenceofdenguens1antigenemiaamonghealthyblooddonorsinatertiarycarehospitalinsouthernindia
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Prevalence of dengue NS1 antigenemia among healthy blood donors in a tertiary care hospital in Southern India

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