Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

Immunostimulatory agents used in cancer treatment often elicit serious toxicities, limiting their clinical application. Here, the authors show that the use of liposomes to intravenously deliver surface-anchored IL-2 and anti-CD137 proteins enables anti-cancer immunity and reduces the toxic side effe...

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Autores principales:	Yuan Zhang, Na Li, Heikyung Suh, Darrell J. Irvine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d4040a0e60d452b9cad0c19ca4f203c
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spelling	oai:doaj.org-article:3d4040a0e60d452b9cad0c19ca4f203c2021-12-02T15:33:46ZNanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity10.1038/s41467-017-02251-32041-1723https://doaj.org/article/3d4040a0e60d452b9cad0c19ca4f203c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02251-3https://doaj.org/toc/2041-1723Immunostimulatory agents used in cancer treatment often elicit serious toxicities, limiting their clinical application. Here, the authors show that the use of liposomes to intravenously deliver surface-anchored IL-2 and anti-CD137 proteins enables anti-cancer immunity and reduces the toxic side effects.Yuan ZhangNa LiHeikyung SuhDarrell J. IrvineNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Zhang Na Li Heikyung Suh Darrell J. Irvine Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
description	Immunostimulatory agents used in cancer treatment often elicit serious toxicities, limiting their clinical application. Here, the authors show that the use of liposomes to intravenously deliver surface-anchored IL-2 and anti-CD137 proteins enables anti-cancer immunity and reduces the toxic side effects.
format	article
author	Yuan Zhang Na Li Heikyung Suh Darrell J. Irvine
author_facet	Yuan Zhang Na Li Heikyung Suh Darrell J. Irvine
author_sort	Yuan Zhang
title	Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
title_short	Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
title_full	Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
title_fullStr	Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
title_full_unstemmed	Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
title_sort	nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3d4040a0e60d452b9cad0c19ca4f203c
work_keys_str_mv	AT yuanzhang nanoparticleanchoringtargetsimmuneagoniststotumorsenablinganticancerimmunitywithoutsystemictoxicity AT nali nanoparticleanchoringtargetsimmuneagoniststotumorsenablinganticancerimmunitywithoutsystemictoxicity AT heikyungsuh nanoparticleanchoringtargetsimmuneagoniststotumorsenablinganticancerimmunitywithoutsystemictoxicity AT darrelljirvine nanoparticleanchoringtargetsimmuneagoniststotumorsenablinganticancerimmunitywithoutsystemictoxicity
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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

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