Glucose promotes cell growth by suppressing branched-chain amino acid degradation

Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-g...

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Autores principales:	Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz, Daniel Raftery, Rong Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d416561e0a045b687c31a78486d0513
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spelling	oai:doaj.org-article:3d416561e0a045b687c31a78486d05132021-12-02T15:33:42ZGlucose promotes cell growth by suppressing branched-chain amino acid degradation10.1038/s41467-018-05362-72041-1723https://doaj.org/article/3d416561e0a045b687c31a78486d05132018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05362-7https://doaj.org/toc/2041-1723Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.Dan ShaoOuti VilletZhen ZhangSung Won ChoiJie YanJulia RitterhoffHaiwei GuDanijel DjukovicDanos ChristodoulouStephen C. KolwiczDaniel RafteryRong TianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian Glucose promotes cell growth by suppressing branched-chain amino acid degradation
description	Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.
format	article
author	Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian
author_facet	Dan Shao Outi Villet Zhen Zhang Sung Won Choi Jie Yan Julia Ritterhoff Haiwei Gu Danijel Djukovic Danos Christodoulou Stephen C. Kolwicz Daniel Raftery Rong Tian
author_sort	Dan Shao
title	Glucose promotes cell growth by suppressing branched-chain amino acid degradation
title_short	Glucose promotes cell growth by suppressing branched-chain amino acid degradation
title_full	Glucose promotes cell growth by suppressing branched-chain amino acid degradation
title_fullStr	Glucose promotes cell growth by suppressing branched-chain amino acid degradation
title_full_unstemmed	Glucose promotes cell growth by suppressing branched-chain amino acid degradation
title_sort	glucose promotes cell growth by suppressing branched-chain amino acid degradation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3d416561e0a045b687c31a78486d0513
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Glucose promotes cell growth by suppressing branched-chain amino acid degradation

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