Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon

Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limba...

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Autor principal:	Mohammed I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3d484b3d5b8e49ffabf7a06b06601d9a
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spelling	oai:doaj.org-article:3d484b3d5b8e49ffabf7a06b06601d9a2021-12-02T01:18:47ZPre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon1177-54671177-5483https://doaj.org/article/3d484b3d5b8e49ffabf7a06b06601d9a2013-01-01T00:00:00Zhttp://www.dovepress.com/pre--and-intraoperative-mitomycin-c-for-recurrent-pterygium-associated-a12055https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive anesthesia (a complete eye block or general anesthesia). Although widely used, safety concerns have been raised over MMC in the treatment of pterygia.Objective: The objective of this case report is to report the successful use of preoperative subconjunctival injection of low-dose (0.02%) MMC one month before bare sclera excision of a multirecurrent pterygium, as well as the concomitant intraoperative application of MMC to the conjunctival fornix of the same eye after the excision of an associated symblepharon.Case report: A 31-year-old man from Kano, Northern Nigeria, presented to the eye clinic with a recurrent pterygium associated with an upper lid symblepharon in his right eye. He has had five previous pterygium excisions, with the last surgery involving conjunctival autografting and subconjunctival steroid injection. He was subsequently given 0.1 mL of 0.02% MMC as a subpterygial injection; one month later he had an alcohol-assisted bare sclera pterygium excision and a symblepharolysis with the intraoperative application of 0.02% MMC for 1 minute to the upper conjunctival fornix. Except for a Tenon granuloma that was simply excised, there has been no recurrence or other complications up to a year after surgery.Conclusion: As a cheaper and technically easier treatment option, a preoperative subconjunctival MMC injection followed by bare sclera pterygium excision was found to be effective in this patient with a recurrent pterygium. As at one-year follow-up, low-dose preoperative MMC a month prior to surgery also appeared safe and effective when combined with its intraoperative application to the conjunctival fornix for the treatment of associated symblepharon.Keywords: mitomycin C, pterygium, recurrence, symblepharonMohammed IDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 199-202 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mohammed I Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
description	Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive anesthesia (a complete eye block or general anesthesia). Although widely used, safety concerns have been raised over MMC in the treatment of pterygia.Objective: The objective of this case report is to report the successful use of preoperative subconjunctival injection of low-dose (0.02%) MMC one month before bare sclera excision of a multirecurrent pterygium, as well as the concomitant intraoperative application of MMC to the conjunctival fornix of the same eye after the excision of an associated symblepharon.Case report: A 31-year-old man from Kano, Northern Nigeria, presented to the eye clinic with a recurrent pterygium associated with an upper lid symblepharon in his right eye. He has had five previous pterygium excisions, with the last surgery involving conjunctival autografting and subconjunctival steroid injection. He was subsequently given 0.1 mL of 0.02% MMC as a subpterygial injection; one month later he had an alcohol-assisted bare sclera pterygium excision and a symblepharolysis with the intraoperative application of 0.02% MMC for 1 minute to the upper conjunctival fornix. Except for a Tenon granuloma that was simply excised, there has been no recurrence or other complications up to a year after surgery.Conclusion: As a cheaper and technically easier treatment option, a preoperative subconjunctival MMC injection followed by bare sclera pterygium excision was found to be effective in this patient with a recurrent pterygium. As at one-year follow-up, low-dose preoperative MMC a month prior to surgery also appeared safe and effective when combined with its intraoperative application to the conjunctival fornix for the treatment of associated symblepharon.Keywords: mitomycin C, pterygium, recurrence, symblepharon
format	article
author	Mohammed I
author_facet	Mohammed I
author_sort	Mohammed I
title	Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
title_short	Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
title_full	Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
title_fullStr	Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
title_full_unstemmed	Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon
title_sort	pre- and intraoperative mitomycin c for recurrent pterygium associated with symblepharon
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/3d484b3d5b8e49ffabf7a06b06601d9a
work_keys_str_mv	AT mohammedi preandintraoperativemitomycincforrecurrentpterygiumassociatedwithsymblepharon
_version_	1718403133332258816

Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon

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