Embedded nanomicro syringe on chip for molecular therapy

Muhammad Arif Jalil1, Nathaporn Suwanpayak2,3, Kathawut Kulsirirat3, Saisudawan Suttirak3, Jalil Ali4, Preecha P Yupapin31Ibnu Sina Institute of Fundamental Science Studies, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2King Mongkut&#39;s Institute...

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Autores principales:	Jalil MA, Suwanpayak N, Kulsirirat K, Suttirak S, Ali J, Yupapin PP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3d4eb4ec74154b31957fc3ed1306cab1
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spelling	oai:doaj.org-article:3d4eb4ec74154b31957fc3ed1306cab12021-12-02T05:09:59ZEmbedded nanomicro syringe on chip for molecular therapy1176-91141178-2013https://doaj.org/article/3d4eb4ec74154b31957fc3ed1306cab12011-11-01T00:00:00Zhttp://www.dovepress.com/embedded-nanomicro-syringe-on-chip-for-molecular-therapy-a8693https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Muhammad Arif Jalil1, Nathaporn Suwanpayak2,3, Kathawut Kulsirirat3, Saisudawan Suttirak3, Jalil Ali4, Preecha P Yupapin31Ibnu Sina Institute of Fundamental Science Studies, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2King Mongkut&#39;s Institute of Technology Ladkrabang, Chumphon Campus, Chumphon, Thailand; 3Nanoscale Science and Engineering Research Alliance, Advanced Research Center for Photonics, Faculty of Science, King Mongkut&#39;s Institute of Technology Ladkrabang, Bangkok, Thailand; 4Institute of Advanced Photonics Science, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, MalaysiaBackground: A novel nanomicro syringe system was proposed for drug storage and delivery using a PANDA ring resonator and atomic buffer. A PANDA ring is a modified optical add/drop filter, named after the well known Chinese bear. In principle, the molecule/drug is trapped by the force generated by different combinations of gradient fields and scattering photons within the PANDA ring. A nanomicro needle system can be formed by optical vortices in the liquid core waveguide which can be embedded on a chip, and can be used for long-term treatment. By using intense optical vortices, the required genes/molecules can be trapped and transported dynamically to the intended destinations via the nanomicro syringe, which is available for drug delivery to target tissues, in particular tumors. The advantage of the proposed system is that by confining the treatment area, the effect can be decreased. The use of different optical vortices for therapeutic efficiency is also discussed.Keywords: nanomicro syringe, nanomicro needle, molecular therapy, therapeutic efficiency, cancerJalil MASuwanpayak NKulsirirat KSuttirak SAli JYupapin PPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2925-2932 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jalil MA Suwanpayak N Kulsirirat K Suttirak S Ali J Yupapin PP Embedded nanomicro syringe on chip for molecular therapy
description	Muhammad Arif Jalil1, Nathaporn Suwanpayak2,3, Kathawut Kulsirirat3, Saisudawan Suttirak3, Jalil Ali4, Preecha P Yupapin31Ibnu Sina Institute of Fundamental Science Studies, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, Malaysia; 2King Mongkut&#39;s Institute of Technology Ladkrabang, Chumphon Campus, Chumphon, Thailand; 3Nanoscale Science and Engineering Research Alliance, Advanced Research Center for Photonics, Faculty of Science, King Mongkut&#39;s Institute of Technology Ladkrabang, Bangkok, Thailand; 4Institute of Advanced Photonics Science, Nanotechnology Research Alliance, Universiti Teknologi Malaysia, Johor Bahru, MalaysiaBackground: A novel nanomicro syringe system was proposed for drug storage and delivery using a PANDA ring resonator and atomic buffer. A PANDA ring is a modified optical add/drop filter, named after the well known Chinese bear. In principle, the molecule/drug is trapped by the force generated by different combinations of gradient fields and scattering photons within the PANDA ring. A nanomicro needle system can be formed by optical vortices in the liquid core waveguide which can be embedded on a chip, and can be used for long-term treatment. By using intense optical vortices, the required genes/molecules can be trapped and transported dynamically to the intended destinations via the nanomicro syringe, which is available for drug delivery to target tissues, in particular tumors. The advantage of the proposed system is that by confining the treatment area, the effect can be decreased. The use of different optical vortices for therapeutic efficiency is also discussed.Keywords: nanomicro syringe, nanomicro needle, molecular therapy, therapeutic efficiency, cancer
format	article
author	Jalil MA Suwanpayak N Kulsirirat K Suttirak S Ali J Yupapin PP
author_facet	Jalil MA Suwanpayak N Kulsirirat K Suttirak S Ali J Yupapin PP
author_sort	Jalil MA
title	Embedded nanomicro syringe on chip for molecular therapy
title_short	Embedded nanomicro syringe on chip for molecular therapy
title_full	Embedded nanomicro syringe on chip for molecular therapy
title_fullStr	Embedded nanomicro syringe on chip for molecular therapy
title_full_unstemmed	Embedded nanomicro syringe on chip for molecular therapy
title_sort	embedded nanomicro syringe on chip for molecular therapy
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/3d4eb4ec74154b31957fc3ed1306cab1
work_keys_str_mv	AT jalilma embeddednanomicrosyringeonchipformoleculartherapy AT suwanpayakn embeddednanomicrosyringeonchipformoleculartherapy AT kulsiriratk embeddednanomicrosyringeonchipformoleculartherapy AT suttiraks embeddednanomicrosyringeonchipformoleculartherapy AT alij embeddednanomicrosyringeonchipformoleculartherapy AT yupapinpp embeddednanomicrosyringeonchipformoleculartherapy
_version_	1718400525028818944

Embedded nanomicro syringe on chip for molecular therapy

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