Evolution of opposing regulatory interactions underlies the emergence of eukaryotic cell cycle checkpoints

Abstract In eukaryotes the entry into mitosis is initiated by activation of cyclin-dependent kinases (CDKs), which in turn activate a large number of protein kinases to induce all mitotic processes. The general view is that kinases are active in mitosis and phosphatases turn them off in interphase....

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Autores principales: Rosa D. Hernansaiz-Ballesteros, Csenge Földi, Luca Cardelli, László G. Nagy, Attila Csikász-Nagy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3d5157b4495846c49c1da2771ff85aae
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