The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment

Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia. Oxidative stress and endoplasmic reticulum...

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Autores principales:	Honoka Fujimori, Takuya Ohba, Masashi Mikami, Shinsuke Nakamura, Kenichi Ito, Hiroyuki Kojima, Tatsuji Takahashi, Arunasiri Iddamalgoda, Masamitsu Shimazawa, Hideaki Hara
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Centella asiatica Araliadiol Oxidative stress Endoplasmic reticulum stress Cognitive dysfunction Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3d55ef5857af4bbaaa120fb1b9bc7cec
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spelling	oai:doaj.org-article:3d55ef5857af4bbaaa120fb1b9bc7cec2021-11-26T04:24:39ZThe protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment1347-861310.1016/j.jphs.2021.11.001https://doaj.org/article/3d55ef5857af4bbaaa120fb1b9bc7cec2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001080https://doaj.org/toc/1347-8613Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia. Oxidative stress and endoplasmic reticulum (ER) stress are increased in the brains of AD patients, and are postulated to induce neuronal cell death and cognitive dysfunction. In this study, Centella asiatica, a traditional Indian medicinal herb, were fractionated and compared for their protective effects against glutamate and tunicamycin damage. Araliadiol was identified as a component from the fraction with the highest activity. Further, murine hippocampal cells (HT22) were damaged by glutamate, an oxidative stress inducer. C. asiatica and araliadiol suppressed cell death and reactive oxygen species production. HT22 cells were also injured by tunicamycin, an ER stress inducer. C. asiatica and araliadiol prevented cell death by mainly inhibiting PERK phosphorylation; additionally, C. asiatica also suppressed the expression levels of GRP94 and BiP. In Y-maze test, oral administration of araliadiol (10 mg/kg/day) for 7 days ameliorated the arm alternation ratio in mice with scopolamine-induced cognitive impairment. These results suggest that C. asiatica and its active component, araliadiol, have neuroprotective effects, which may prevent cognitive dysfunction.Honoka FujimoriTakuya OhbaMasashi MikamiShinsuke NakamuraKenichi ItoHiroyuki KojimaTatsuji TakahashiArunasiri IddamalgodaMasamitsu ShimazawaHideaki HaraElsevierarticleCentella asiaticaAraliadiolOxidative stressEndoplasmic reticulum stressCognitive dysfunctionTherapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 162-171 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Centella asiatica Araliadiol Oxidative stress Endoplasmic reticulum stress Cognitive dysfunction Therapeutics. Pharmacology RM1-950
spellingShingle	Centella asiatica Araliadiol Oxidative stress Endoplasmic reticulum stress Cognitive dysfunction Therapeutics. Pharmacology RM1-950 Honoka Fujimori Takuya Ohba Masashi Mikami Shinsuke Nakamura Kenichi Ito Hiroyuki Kojima Tatsuji Takahashi Arunasiri Iddamalgoda Masamitsu Shimazawa Hideaki Hara The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
description	Alzheimer's disease (AD) is characterized by progressive cognitive decline, and the number of affected individuals has increased worldwide. However, there are no effective treatments for AD. Therefore, it is important to prevent the onset of dementia. Oxidative stress and endoplasmic reticulum (ER) stress are increased in the brains of AD patients, and are postulated to induce neuronal cell death and cognitive dysfunction. In this study, Centella asiatica, a traditional Indian medicinal herb, were fractionated and compared for their protective effects against glutamate and tunicamycin damage. Araliadiol was identified as a component from the fraction with the highest activity. Further, murine hippocampal cells (HT22) were damaged by glutamate, an oxidative stress inducer. C. asiatica and araliadiol suppressed cell death and reactive oxygen species production. HT22 cells were also injured by tunicamycin, an ER stress inducer. C. asiatica and araliadiol prevented cell death by mainly inhibiting PERK phosphorylation; additionally, C. asiatica also suppressed the expression levels of GRP94 and BiP. In Y-maze test, oral administration of araliadiol (10 mg/kg/day) for 7 days ameliorated the arm alternation ratio in mice with scopolamine-induced cognitive impairment. These results suggest that C. asiatica and its active component, araliadiol, have neuroprotective effects, which may prevent cognitive dysfunction.
format	article
author	Honoka Fujimori Takuya Ohba Masashi Mikami Shinsuke Nakamura Kenichi Ito Hiroyuki Kojima Tatsuji Takahashi Arunasiri Iddamalgoda Masamitsu Shimazawa Hideaki Hara
author_facet	Honoka Fujimori Takuya Ohba Masashi Mikami Shinsuke Nakamura Kenichi Ito Hiroyuki Kojima Tatsuji Takahashi Arunasiri Iddamalgoda Masamitsu Shimazawa Hideaki Hara
author_sort	Honoka Fujimori
title	The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
title_short	The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
title_full	The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
title_fullStr	The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
title_full_unstemmed	The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
title_sort	protective effect of centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/3d55ef5857af4bbaaa120fb1b9bc7cec
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The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment

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