Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease

<h4>Background</h4> Young South African women are faced with a dual epidemic of HIV and obesity, placing them at a high risk of developing atherosclerotic cardiovascular disease (CVD). We sought to determine the prevalence of CVD risk factors in a cohort of reproductive-aged South Africa...

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Autores principales:	Sherika Hanley, Dhayendre Moodley, Mergan Naidoo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d5a6bcd99d0404393321fa0f939afe3
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spelling	oai:doaj.org-article:3d5a6bcd99d0404393321fa0f939afe32021-11-25T05:54:27ZObesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease1932-6203https://doaj.org/article/3d5a6bcd99d0404393321fa0f939afe32021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592426/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Young South African women are faced with a dual epidemic of HIV and obesity, placing them at a high risk of developing atherosclerotic cardiovascular disease (CVD). We sought to determine the prevalence of CVD risk factors in a cohort of reproductive-aged South African women living with HIV (WLHIV). <h4>Methods</h4> While the main purpose of an ongoing intervention study is the reduction of cardiovascular disease through the integration of CVD screening and prevention in the HIV management plan for women of reproductive age (ISCHeMiA trial), we present the prevalence of risk factors for CVD in this cohort of young women at baseline. Sociodemographic, conventional CVD risk factors, HIV-related factors and self body image perception were assessed through study questionnaires and standardized clinical and laboratory procedures. <h4>Results</h4> Of the 372 WLHIV enrolled from November 2018 to May 2019, 97% had received efavirenz-based antiretroviral treatment (ART) for at least 1 year and 67.5% (248/367) of women were overweight or obese at the time of enrolment. The prevalence of metabolic syndrome was 17.6% (95%CI 11.6–22.8) at a median age of 35 years (IQR 30.5–40.5). A significant proportion of women had abnormally low levels of high-density lipoprotein (43.2%, 80/185) and elevated levels of high sensitivity C-reactive protein (59.5%, 110/185). Seventy five percent of overweight women with an increased waist circumference reported to be satisfied with their body image. <h4>Conclusions</h4> The high prevalence of metabolic syndrome, obesity and elevated markers of inflammation in young South African WLHIV, underscores the need for a proactive integrated management approach to prevent atherosclerotic cardiovascular disease in low and middle income settings.Sherika HanleyDhayendre MoodleyMergan NaidooPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sherika Hanley Dhayendre Moodley Mergan Naidoo Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
description	<h4>Background</h4> Young South African women are faced with a dual epidemic of HIV and obesity, placing them at a high risk of developing atherosclerotic cardiovascular disease (CVD). We sought to determine the prevalence of CVD risk factors in a cohort of reproductive-aged South African women living with HIV (WLHIV). <h4>Methods</h4> While the main purpose of an ongoing intervention study is the reduction of cardiovascular disease through the integration of CVD screening and prevention in the HIV management plan for women of reproductive age (ISCHeMiA trial), we present the prevalence of risk factors for CVD in this cohort of young women at baseline. Sociodemographic, conventional CVD risk factors, HIV-related factors and self body image perception were assessed through study questionnaires and standardized clinical and laboratory procedures. <h4>Results</h4> Of the 372 WLHIV enrolled from November 2018 to May 2019, 97% had received efavirenz-based antiretroviral treatment (ART) for at least 1 year and 67.5% (248/367) of women were overweight or obese at the time of enrolment. The prevalence of metabolic syndrome was 17.6% (95%CI 11.6–22.8) at a median age of 35 years (IQR 30.5–40.5). A significant proportion of women had abnormally low levels of high-density lipoprotein (43.2%, 80/185) and elevated levels of high sensitivity C-reactive protein (59.5%, 110/185). Seventy five percent of overweight women with an increased waist circumference reported to be satisfied with their body image. <h4>Conclusions</h4> The high prevalence of metabolic syndrome, obesity and elevated markers of inflammation in young South African WLHIV, underscores the need for a proactive integrated management approach to prevent atherosclerotic cardiovascular disease in low and middle income settings.
format	article
author	Sherika Hanley Dhayendre Moodley Mergan Naidoo
author_facet	Sherika Hanley Dhayendre Moodley Mergan Naidoo
author_sort	Sherika Hanley
title	Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
title_short	Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
title_full	Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
title_fullStr	Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
title_full_unstemmed	Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease
title_sort	obesity in young south african women living with hiv: a cross-sectional analysis of risk factors for cardiovascular disease
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3d5a6bcd99d0404393321fa0f939afe3
work_keys_str_mv	AT sherikahanley obesityinyoungsouthafricanwomenlivingwithhivacrosssectionalanalysisofriskfactorsforcardiovasculardisease AT dhayendremoodley obesityinyoungsouthafricanwomenlivingwithhivacrosssectionalanalysisofriskfactorsforcardiovasculardisease AT mergannaidoo obesityinyoungsouthafricanwomenlivingwithhivacrosssectionalanalysisofriskfactorsforcardiovasculardisease
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Obesity in young South African women living with HIV: A cross-sectional analysis of risk factors for cardiovascular disease

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