Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study

Abstract The role of ST2 in stable coronary artery disease (CAD) has not yet been well defined. This study was performed to investigate baseline serum soluble ST2 (sST2) level can predict clinical outcomes in patients with stable CAD. A total of 388 consecutive patients with suspected CAD (65 years...

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Autores principales:	Hack-Lyoung Kim, Jung Pyo Lee, Nathan Wong, Woo-Hyun Lim, Jae-Bin Seo, Joo-Hee Zo, Myung-A Kim, Sang-Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d5b5536482f4babb0653e899e2ec6a1
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spelling	oai:doaj.org-article:3d5b5536482f4babb0653e899e2ec6a12021-12-02T18:46:57ZPrognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study10.1038/s41598-021-94714-32045-2322https://doaj.org/article/3d5b5536482f4babb0653e899e2ec6a12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94714-3https://doaj.org/toc/2045-2322Abstract The role of ST2 in stable coronary artery disease (CAD) has not yet been well defined. This study was performed to investigate baseline serum soluble ST2 (sST2) level can predict clinical outcomes in patients with stable CAD. A total of 388 consecutive patients with suspected CAD (65 years and 63.7% male) in stable condition referred for elective invasive coronary angiography (ICA) was prospectively recruited. Major adverse cardiovascular event (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization (90 days after ICA), and ischemic stroke during clinical follow-up was assessed. Most of the patients (88.0%) had significant CAD (stenosis ≥ 50%). During median follow-up of 834 days, there was 29 case of MACE (7.5%). The serum sST2 level was significantly higher in patients with MACE than those without (47.3 versus 30.6 ng/ml, P < 0.001). In multiple Cox regression model, higher sST2 level (≥ 26.8 ng/ml) was an independent predictor of MACE even after controlling potential confounders (hazard ratio, 13.7; 95% confidence interval 1.80–104.60; P = 0.011). The elevated level of baseline sST2 is associated with an increased risk of adverse clinical events in stable CAD patients. Studies with larger sample size are needed to confirm our findings.Hack-Lyoung KimJung Pyo LeeNathan WongWoo-Hyun LimJae-Bin SeoJoo-Hee ZoMyung-A KimSang-Hyun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hack-Lyoung Kim Jung Pyo Lee Nathan Wong Woo-Hyun Lim Jae-Bin Seo Joo-Hee Zo Myung-A Kim Sang-Hyun Kim Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
description	Abstract The role of ST2 in stable coronary artery disease (CAD) has not yet been well defined. This study was performed to investigate baseline serum soluble ST2 (sST2) level can predict clinical outcomes in patients with stable CAD. A total of 388 consecutive patients with suspected CAD (65 years and 63.7% male) in stable condition referred for elective invasive coronary angiography (ICA) was prospectively recruited. Major adverse cardiovascular event (MACE), including cardiac death, non-fatal myocardial infarction, coronary revascularization (90 days after ICA), and ischemic stroke during clinical follow-up was assessed. Most of the patients (88.0%) had significant CAD (stenosis ≥ 50%). During median follow-up of 834 days, there was 29 case of MACE (7.5%). The serum sST2 level was significantly higher in patients with MACE than those without (47.3 versus 30.6 ng/ml, P < 0.001). In multiple Cox regression model, higher sST2 level (≥ 26.8 ng/ml) was an independent predictor of MACE even after controlling potential confounders (hazard ratio, 13.7; 95% confidence interval 1.80–104.60; P = 0.011). The elevated level of baseline sST2 is associated with an increased risk of adverse clinical events in stable CAD patients. Studies with larger sample size are needed to confirm our findings.
format	article
author	Hack-Lyoung Kim Jung Pyo Lee Nathan Wong Woo-Hyun Lim Jae-Bin Seo Joo-Hee Zo Myung-A Kim Sang-Hyun Kim
author_facet	Hack-Lyoung Kim Jung Pyo Lee Nathan Wong Woo-Hyun Lim Jae-Bin Seo Joo-Hee Zo Myung-A Kim Sang-Hyun Kim
author_sort	Hack-Lyoung Kim
title	Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
title_short	Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
title_full	Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
title_fullStr	Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
title_full_unstemmed	Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study
title_sort	prognostic value of serum soluble st2 in stable coronary artery disease: a prospective observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d5b5536482f4babb0653e899e2ec6a1
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Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study

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