Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction

Amrita DosanjhDepartment of Pediatrics, Rady Children’s Hospital, San Diego, CA, USABackground: Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at risk for development of allograft reject...

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Autor principal:	Dosanjh A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3d5ba82739344d6a939ad3fd437ea934
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spelling	oai:doaj.org-article:3d5ba82739344d6a939ad3fd437ea9342021-12-02T02:04:19ZRespiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction1178-7031https://doaj.org/article/3d5ba82739344d6a939ad3fd437ea9342015-03-01T00:00:00Zhttp://www.dovepress.com/respiratory-metapneumoviral-infection-without-co-infection-in-associat-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031 Amrita DosanjhDepartment of Pediatrics, Rady Children’s Hospital, San Diego, CA, USABackground: Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at risk for development of allograft rejection. The cellular and molecular pathways initiated by viral infection leading to allograft dysfunction are not completely understood. The aim of this study was to identify human metapneumoviral (hMPV) cases in association with allograft rejection.Methods: A literature search was conducted to identify cases of both hMPV and allograft rejection within 6 months of the initial infection. This resulted in 1,007 lung transplantation recipients, with a total of 2,883 samples identified. Of these, 57 demonstrated isolated hMPV without co-infection with other agents.Results: The results of the study indicate that 35% of acute hMPV infections without co-infection, at the time of detection by molecular diagnostic platforms, were associated with acute cellular rejection within 3 months. There were 9.4% of the cases subsequently associated with chronic allograft dysfunction/bronchiolitis obliterans syndrome, which was collectively termed chronic rejection for purposes of analysis. In conclusion, the prompt identification of isolated hMPV from lung transplantation patients is an important treatable risk factor for subsequent allograft dysfunction. The cellular and molecular pathogenesis of viral-induced allograft rejection remains a topic of future study.Keywords: viral infection, bronchiolitis obliterans, acute cellular rejection, allograft, lung, metapneumovirusDosanjh ADove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2015, Iss default, Pp 79-82 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Dosanjh A Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
description	Amrita DosanjhDepartment of Pediatrics, Rady Children’s Hospital, San Diego, CA, USABackground: Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at risk for development of allograft rejection. The cellular and molecular pathways initiated by viral infection leading to allograft dysfunction are not completely understood. The aim of this study was to identify human metapneumoviral (hMPV) cases in association with allograft rejection.Methods: A literature search was conducted to identify cases of both hMPV and allograft rejection within 6 months of the initial infection. This resulted in 1,007 lung transplantation recipients, with a total of 2,883 samples identified. Of these, 57 demonstrated isolated hMPV without co-infection with other agents.Results: The results of the study indicate that 35% of acute hMPV infections without co-infection, at the time of detection by molecular diagnostic platforms, were associated with acute cellular rejection within 3 months. There were 9.4% of the cases subsequently associated with chronic allograft dysfunction/bronchiolitis obliterans syndrome, which was collectively termed chronic rejection for purposes of analysis. In conclusion, the prompt identification of isolated hMPV from lung transplantation patients is an important treatable risk factor for subsequent allograft dysfunction. The cellular and molecular pathogenesis of viral-induced allograft rejection remains a topic of future study.Keywords: viral infection, bronchiolitis obliterans, acute cellular rejection, allograft, lung, metapneumovirus
format	article
author	Dosanjh A
author_facet	Dosanjh A
author_sort	Dosanjh A
title	Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
title_short	Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
title_full	Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
title_fullStr	Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
title_full_unstemmed	Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
title_sort	respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3d5ba82739344d6a939ad3fd437ea934
work_keys_str_mv	AT dosanjha respiratorymetapneumoviralinfectionwithoutcoinfectioninassociationwithacuteandchroniclungallograftdysfunction
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Respiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction

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