Test–retest reliability of laser evoked pain perception and fMRI BOLD responses

Abstract Pain perception is a subjective experience and highly variable across time. Brain responses evoked by nociceptive stimuli are highly associated with pain perception and also showed considerable variability. To date, the test–retest reliability of laser-evoked pain perception and its associa...

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Autores principales:	Yanzhi Bi, Xin Hou, Jiahui Zhong, Li Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d5c3a83f65e4547aff1fdce44050aee
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spelling	oai:doaj.org-article:3d5c3a83f65e4547aff1fdce44050aee2021-12-02T14:12:10ZTest–retest reliability of laser evoked pain perception and fMRI BOLD responses10.1038/s41598-020-79196-z2045-2322https://doaj.org/article/3d5c3a83f65e4547aff1fdce44050aee2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79196-zhttps://doaj.org/toc/2045-2322Abstract Pain perception is a subjective experience and highly variable across time. Brain responses evoked by nociceptive stimuli are highly associated with pain perception and also showed considerable variability. To date, the test–retest reliability of laser-evoked pain perception and its associated brain responses across sessions remain unclear. Here, an experiment with a within-subject repeated-measures design was performed in 22 healthy volunteers. Radiant-heat laser stimuli were delivered on subjects’ left-hand dorsum in two sessions separated by 1–5 days. We observed that laser-evoked pain perception was significantly declined across sessions, coupled with decreased brain responses in the bilateral primary somatosensory cortex (S1), right primary motor cortex, supplementary motor area, and middle cingulate cortex. Intraclass correlation coefficients between the two sessions showed “fair” to “moderate” test–retest reliability for pain perception and brain responses. Additionally, we observed lower resting-state brain activity in the right S1 and lower resting-state functional connectivity between right S1 and dorsolateral prefrontal cortex in the second session than the first session. Altogether, being possibly influenced by changes of baseline mental state, laser-evoked pain perception and brain responses showed considerable across-session variability. This phenomenon should be considered when designing experiments for laboratory studies and evaluating pain abnormalities in clinical practice.Yanzhi BiXin HouJiahui ZhongLi HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanzhi Bi Xin Hou Jiahui Zhong Li Hu Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
description	Abstract Pain perception is a subjective experience and highly variable across time. Brain responses evoked by nociceptive stimuli are highly associated with pain perception and also showed considerable variability. To date, the test–retest reliability of laser-evoked pain perception and its associated brain responses across sessions remain unclear. Here, an experiment with a within-subject repeated-measures design was performed in 22 healthy volunteers. Radiant-heat laser stimuli were delivered on subjects’ left-hand dorsum in two sessions separated by 1–5 days. We observed that laser-evoked pain perception was significantly declined across sessions, coupled with decreased brain responses in the bilateral primary somatosensory cortex (S1), right primary motor cortex, supplementary motor area, and middle cingulate cortex. Intraclass correlation coefficients between the two sessions showed “fair” to “moderate” test–retest reliability for pain perception and brain responses. Additionally, we observed lower resting-state brain activity in the right S1 and lower resting-state functional connectivity between right S1 and dorsolateral prefrontal cortex in the second session than the first session. Altogether, being possibly influenced by changes of baseline mental state, laser-evoked pain perception and brain responses showed considerable across-session variability. This phenomenon should be considered when designing experiments for laboratory studies and evaluating pain abnormalities in clinical practice.
format	article
author	Yanzhi Bi Xin Hou Jiahui Zhong Li Hu
author_facet	Yanzhi Bi Xin Hou Jiahui Zhong Li Hu
author_sort	Yanzhi Bi
title	Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
title_short	Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
title_full	Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
title_fullStr	Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
title_full_unstemmed	Test–retest reliability of laser evoked pain perception and fMRI BOLD responses
title_sort	test–retest reliability of laser evoked pain perception and fmri bold responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d5c3a83f65e4547aff1fdce44050aee
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_version_	1718391779826335744

Test–retest reliability of laser evoked pain perception and fMRI BOLD responses

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