Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment

Abstract Our aim was to evaluate the circadian rhythm of motor activity, body position and integrated variable TAP (composed by wrist Temperature, motor Activity and body Position) in Sleep Disordered Breathing (SDB), its relation to SDB severity and the effect of continuous positive airway pressure...

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Autores principales:	Antonio Martinez-Nicolas, Marc Guaita, Joan Santamaría, Josep M. Montserrat, Juan Antonio Madrid, María Angeles Rol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d5f53c5a5f04fe6afbd785356276796
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spelling	oai:doaj.org-article:3d5f53c5a5f04fe6afbd7853562767962021-12-02T16:26:30ZAmbulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment10.1038/s41598-021-94315-02045-2322https://doaj.org/article/3d5f53c5a5f04fe6afbd7853562767962021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94315-0https://doaj.org/toc/2045-2322Abstract Our aim was to evaluate the circadian rhythm of motor activity, body position and integrated variable TAP (composed by wrist Temperature, motor Activity and body Position) in Sleep Disordered Breathing (SDB), its relation to SDB severity and the effect of continuous positive airway pressure (CPAP) on these circadian rhythms. To do this, we monitored motor activity and body position rhythms of 78 SDB patients (53.3 ± 1.2 years old, 26.9% women) and 32 healthy subjects (51.4 ± 3.2 years old, 43.8% women) for 1 week. On the last day of that week, SDB patients underwent a polysomnography followed by a Maintenance of Wakefulness Test, Multiple Sleep Latency Test and Sustained Attention to Response Task protocol. A subgroup of 18 moderate to severe SDB patients was treated with CPAP and monitored again after 3 months under treatment. A non-parametrical analysis was performed to characterize the circadian patterns to assess differences between groups and associations between sleep and circadian parameters. Circadian variables were altered in SDB, exhibiting a direct relationship to SDB severity. The motor activity pattern showed a clear improvement with CPAP treatment. Thus, circadian ambulatory monitoring, including the integrated variable TAP, could be used to evaluate the circadian alterations caused by SDB and activity pattern to monitor the effect of CPAP treatment.Antonio Martinez-NicolasMarc GuaitaJoan SantamaríaJosep M. MontserratJuan Antonio MadridMaría Angeles RolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio Martinez-Nicolas Marc Guaita Joan Santamaría Josep M. Montserrat Juan Antonio Madrid María Angeles Rol Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
description	Abstract Our aim was to evaluate the circadian rhythm of motor activity, body position and integrated variable TAP (composed by wrist Temperature, motor Activity and body Position) in Sleep Disordered Breathing (SDB), its relation to SDB severity and the effect of continuous positive airway pressure (CPAP) on these circadian rhythms. To do this, we monitored motor activity and body position rhythms of 78 SDB patients (53.3 ± 1.2 years old, 26.9% women) and 32 healthy subjects (51.4 ± 3.2 years old, 43.8% women) for 1 week. On the last day of that week, SDB patients underwent a polysomnography followed by a Maintenance of Wakefulness Test, Multiple Sleep Latency Test and Sustained Attention to Response Task protocol. A subgroup of 18 moderate to severe SDB patients was treated with CPAP and monitored again after 3 months under treatment. A non-parametrical analysis was performed to characterize the circadian patterns to assess differences between groups and associations between sleep and circadian parameters. Circadian variables were altered in SDB, exhibiting a direct relationship to SDB severity. The motor activity pattern showed a clear improvement with CPAP treatment. Thus, circadian ambulatory monitoring, including the integrated variable TAP, could be used to evaluate the circadian alterations caused by SDB and activity pattern to monitor the effect of CPAP treatment.
format	article
author	Antonio Martinez-Nicolas Marc Guaita Joan Santamaría Josep M. Montserrat Juan Antonio Madrid María Angeles Rol
author_facet	Antonio Martinez-Nicolas Marc Guaita Joan Santamaría Josep M. Montserrat Juan Antonio Madrid María Angeles Rol
author_sort	Antonio Martinez-Nicolas
title	Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
title_short	Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
title_full	Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
title_fullStr	Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
title_full_unstemmed	Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment
title_sort	ambulatory circadian monitoring in sleep disordered breathing patients and cpap treatment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d5f53c5a5f04fe6afbd785356276796
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Ambulatory circadian monitoring in sleep disordered breathing patients and CPAP treatment

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