Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.

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Autores principales:	Elizabeth L. Christie, Swetansu Pattnaik, Jessica Beach, Anthony Copeland, Nineveh Rashoo, Sian Fereday, Joy Hendley, Kathryn Alsop, Samuel L. Brady, Greg Lamb, Ahwan Pandey, Anna deFazio, Heather Thorne, Andrea Bild, David D. L. Bowtell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d60dcd89a874c7d9dd75f1ea6c6ed3b
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spelling	oai:doaj.org-article:3d60dcd89a874c7d9dd75f1ea6c6ed3b2021-12-02T17:02:08ZMultiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer10.1038/s41467-019-09312-92041-1723https://doaj.org/article/3d60dcd89a874c7d9dd75f1ea6c6ed3b2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09312-9https://doaj.org/toc/2041-1723ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.Elizabeth L. ChristieSwetansu PattnaikJessica BeachAnthony CopelandNineveh RashooSian FeredayJoy HendleyKathryn AlsopSamuel L. BradyGreg LambAhwan PandeyAnna deFazioHeather ThorneAndrea BildDavid D. L. BowtellNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth L. Christie Swetansu Pattnaik Jessica Beach Anthony Copeland Nineveh Rashoo Sian Fereday Joy Hendley Kathryn Alsop Samuel L. Brady Greg Lamb Ahwan Pandey Anna deFazio Heather Thorne Andrea Bild David D. L. Bowtell Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
description	ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.
format	article
author	Elizabeth L. Christie Swetansu Pattnaik Jessica Beach Anthony Copeland Nineveh Rashoo Sian Fereday Joy Hendley Kathryn Alsop Samuel L. Brady Greg Lamb Ahwan Pandey Anna deFazio Heather Thorne Andrea Bild David D. L. Bowtell
author_facet	Elizabeth L. Christie Swetansu Pattnaik Jessica Beach Anthony Copeland Nineveh Rashoo Sian Fereday Joy Hendley Kathryn Alsop Samuel L. Brady Greg Lamb Ahwan Pandey Anna deFazio Heather Thorne Andrea Bild David D. L. Bowtell
author_sort	Elizabeth L. Christie
title	Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
title_short	Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
title_full	Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
title_fullStr	Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
title_full_unstemmed	Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
title_sort	multiple abcb1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3d60dcd89a874c7d9dd75f1ea6c6ed3b
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Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

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