Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization signals into the central channel for directed nuc...

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Autores principales:	Krishna C. Mudumbi, Rafal Czapiewski, Andrew Ruba, Samuel L. Junod, Yichen Li, Wangxi Luo, Christina Ngo, Valentina Ospina, Eric C. Schirmer, Weidong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d614e823838402aa8b9ff0997e812ae
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spelling	oai:doaj.org-article:3d614e823838402aa8b9ff0997e812ae2021-12-02T14:41:24ZNucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores10.1038/s41467-020-16033-x2041-1723https://doaj.org/article/3d614e823838402aa8b9ff0997e812ae2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16033-xhttps://doaj.org/toc/2041-1723The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization signals into the central channel for directed nuclear transport.Krishna C. MudumbiRafal CzapiewskiAndrew RubaSamuel L. JunodYichen LiWangxi LuoChristina NgoValentina OspinaEric C. SchirmerWeidong YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna C. Mudumbi Rafal Czapiewski Andrew Ruba Samuel L. Junod Yichen Li Wangxi Luo Christina Ngo Valentina Ospina Eric C. Schirmer Weidong Yang Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
description	The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization signals into the central channel for directed nuclear transport.
format	article
author	Krishna C. Mudumbi Rafal Czapiewski Andrew Ruba Samuel L. Junod Yichen Li Wangxi Luo Christina Ngo Valentina Ospina Eric C. Schirmer Weidong Yang
author_facet	Krishna C. Mudumbi Rafal Czapiewski Andrew Ruba Samuel L. Junod Yichen Li Wangxi Luo Christina Ngo Valentina Ospina Eric C. Schirmer Weidong Yang
author_sort	Krishna C. Mudumbi
title	Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
title_short	Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
title_full	Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
title_fullStr	Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
title_full_unstemmed	Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
title_sort	nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3d614e823838402aa8b9ff0997e812ae
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Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

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