Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential...

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Autores principales:	Jacqueline A. Maybin, Alison A. Murray, Philippa T. K. Saunders, Nikhil Hirani, Peter Carmeliet, Hilary O. D. Critchley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d625696cf6342b79ac265446a69ab16
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spelling	oai:doaj.org-article:3d625696cf6342b79ac265446a69ab162021-12-02T15:33:56ZHypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation10.1038/s41467-017-02375-62041-1723https://doaj.org/article/3d625696cf6342b79ac265446a69ab162018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02375-6https://doaj.org/toc/2041-1723About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.Jacqueline A. MaybinAlison A. MurrayPhilippa T. K. SaundersNikhil HiraniPeter CarmelietHilary O. D. CritchleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
description	About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.
format	article
author	Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley
author_facet	Jacqueline A. Maybin Alison A. Murray Philippa T. K. Saunders Nikhil Hirani Peter Carmeliet Hilary O. D. Critchley
author_sort	Jacqueline A. Maybin
title	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_short	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_full	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_fullStr	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_full_unstemmed	Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
title_sort	hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3d625696cf6342b79ac265446a69ab16
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Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

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