Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype

The bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes...

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Autores principales:	Benjamin Kostiuk, Francis J. Santoriello, Laura Diaz-Satizabal, Fabiana Bisaro, Kyung-Jo Lee, Anna N. Dhody, Daniele Provenzano, Daniel Unterweger, Stefan Pukatzki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d629ab816704df4bbda22e3c61d8c4a
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spelling	oai:doaj.org-article:3d629ab816704df4bbda22e3c61d8c4a2021-11-14T12:36:13ZType VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype10.1038/s41467-021-26847-y2041-1723https://doaj.org/article/3d629ab816704df4bbda22e3c61d8c4a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26847-yhttps://doaj.org/toc/2041-1723The bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes that disadvantaged them when confronted with 7th pandemic El Tor biotype strains.Benjamin KostiukFrancis J. SantorielloLaura Diaz-SatizabalFabiana BisaroKyung-Jo LeeAnna N. DhodyDaniele ProvenzanoDaniel UnterwegerStefan PukatzkiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
description	The bacterium Vibrio cholerae has caused seven recorded cholera pandemics. The factors responsible for the decline of 6th pandemic classical biotype strains are not well understood. Here, Kostiuk et al. propose that classical strains underwent sequential mutations in type-six secretion system genes that disadvantaged them when confronted with 7th pandemic El Tor biotype strains.
format	article
author	Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki
author_facet	Benjamin Kostiuk Francis J. Santoriello Laura Diaz-Satizabal Fabiana Bisaro Kyung-Jo Lee Anna N. Dhody Daniele Provenzano Daniel Unterweger Stefan Pukatzki
author_sort	Benjamin Kostiuk
title	Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
title_short	Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
title_full	Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
title_fullStr	Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
title_full_unstemmed	Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype
title_sort	type vi secretion system mutations reduced competitive fitness of classical vibrio cholerae biotype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d629ab816704df4bbda22e3c61d8c4a
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Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype

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