Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis

Abstract Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ping-Yen Tsai, Yang-Ching Chen, Jia-Yi Wang, Kuo-Hsuan Chung, Chien-Hung Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d6491dadb1b48fb954f2655aa39cbfb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3d6491dadb1b48fb954f2655aa39cbfb
record_format	dspace
spelling	oai:doaj.org-article:3d6491dadb1b48fb954f2655aa39cbfb2021-12-02T18:51:47ZEffect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis10.1038/s41598-021-95838-22045-2322https://doaj.org/article/3d6491dadb1b48fb954f2655aa39cbfb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95838-2https://doaj.org/toc/2045-2322Abstract Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over dorsolateral prefrontal cortex (DLPFC) on depression, cognitive impairment and post-concussion syndrome in individuals with traumatic brain injury. This study contained seven randomized controlled trials that published before April 5, 2020 in PubMed, Embase, Scopus, Cochrane, and Web of Science databases. The rTMS had significant anti-depressant effect (SMD = 1.03, p = 0.02), but the effects dissipated at 1-month follow-up (SMD = 0.39, p = 0.62). In the subgroup analysis, only applying rTMS to left DLPFC area of post-TBI patients showed significant anti-depressant effect (SMD = 0.98, p = 0.04). Moreover, current data observed that rTMS on post-TBI patients possessed substantial improvement in visuospatial memory (SMD = 0.39, p < 0.0001), but wasn’t in processing speed (SMD = − 0.18, p = 0.32) and selective attention (SMD = 0.21, p = 0.31). In addition, the effect of rTMS is not superior to sham on postconcussion syndrome. In conclusion, the short-term antidepressant effect of left DLPFC rTMS in patients with TBI was significant. However, the effectiveness of rTMS on cognition and postconcussion syndrome in patients with post-TBI depression was limited.Ping-Yen TsaiYang-Ching ChenJia-Yi WangKuo-Hsuan ChungChien-Hung LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping-Yen Tsai Yang-Ching Chen Jia-Yi Wang Kuo-Hsuan Chung Chien-Hung Lai Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
description	Abstract Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over dorsolateral prefrontal cortex (DLPFC) on depression, cognitive impairment and post-concussion syndrome in individuals with traumatic brain injury. This study contained seven randomized controlled trials that published before April 5, 2020 in PubMed, Embase, Scopus, Cochrane, and Web of Science databases. The rTMS had significant anti-depressant effect (SMD = 1.03, p = 0.02), but the effects dissipated at 1-month follow-up (SMD = 0.39, p = 0.62). In the subgroup analysis, only applying rTMS to left DLPFC area of post-TBI patients showed significant anti-depressant effect (SMD = 0.98, p = 0.04). Moreover, current data observed that rTMS on post-TBI patients possessed substantial improvement in visuospatial memory (SMD = 0.39, p < 0.0001), but wasn’t in processing speed (SMD = − 0.18, p = 0.32) and selective attention (SMD = 0.21, p = 0.31). In addition, the effect of rTMS is not superior to sham on postconcussion syndrome. In conclusion, the short-term antidepressant effect of left DLPFC rTMS in patients with TBI was significant. However, the effectiveness of rTMS on cognition and postconcussion syndrome in patients with post-TBI depression was limited.
format	article
author	Ping-Yen Tsai Yang-Ching Chen Jia-Yi Wang Kuo-Hsuan Chung Chien-Hung Lai
author_facet	Ping-Yen Tsai Yang-Ching Chen Jia-Yi Wang Kuo-Hsuan Chung Chien-Hung Lai
author_sort	Ping-Yen Tsai
title	Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
title_short	Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
title_full	Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
title_fullStr	Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
title_full_unstemmed	Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
title_sort	effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d6491dadb1b48fb954f2655aa39cbfb
work_keys_str_mv	AT pingyentsai effectofrepetitivetranscranialmagneticstimulationondepressionandcognitioninindividualswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT yangchingchen effectofrepetitivetranscranialmagneticstimulationondepressionandcognitioninindividualswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT jiayiwang effectofrepetitivetranscranialmagneticstimulationondepressionandcognitioninindividualswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT kuohsuanchung effectofrepetitivetranscranialmagneticstimulationondepressionandcognitioninindividualswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT chienhunglai effectofrepetitivetranscranialmagneticstimulationondepressionandcognitioninindividualswithtraumaticbraininjuryasystematicreviewandmetaanalysis
_version_	1718377379593715712

Effect of repetitive transcranial magnetic stimulation on depression and cognition in individuals with traumatic brain injury: a systematic review and meta-analysis

Ejemplares similares