The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme-intermediate and product complexes, which is importan...

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Autores principales:	Han Feng, Xuehui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang, Wei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d6920df3c794045acc9dd9cd1b32ccc
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spelling	oai:doaj.org-article:3d6920df3c794045acc9dd9cd1b32ccc2021-12-02T17:06:12ZThe mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis10.1038/s41467-017-02339-w2041-1723https://doaj.org/article/3d6920df3c794045acc9dd9cd1b32ccc2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02339-whttps://doaj.org/toc/2041-1723New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme-intermediate and product complexes, which is important for drug design.Han FengXuehui LiuSheng WangJoy FlemingDa-Cheng WangWei LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Han Feng Xuehui Liu Sheng Wang Joy Fleming Da-Cheng Wang Wei Liu The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
description	New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme-intermediate and product complexes, which is important for drug design.
format	article
author	Han Feng Xuehui Liu Sheng Wang Joy Fleming Da-Cheng Wang Wei Liu
author_facet	Han Feng Xuehui Liu Sheng Wang Joy Fleming Da-Cheng Wang Wei Liu
author_sort	Han Feng
title	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
title_short	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
title_full	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
title_fullStr	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
title_full_unstemmed	The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
title_sort	mechanism of ndm-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d6920df3c794045acc9dd9cd1b32ccc
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The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

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