Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.

This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sec...

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Autores principales:	Beesan Maraqa, Walid Basha, Rasha Khayyat, Abdul-Rahman Abdul-Hadi, Jurouh Jabareen, Kamal Al-Shakhra, Mai Al-Kaila, Zaher Nazzal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d694a84060440f0bacd9d72e291db51
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spelling	oai:doaj.org-article:3d694a84060440f0bacd9d72e291db512021-11-25T05:54:12ZPrevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.1932-620310.1371/journal.pone.0258255https://doaj.org/article/3d694a84060440f0bacd9d72e291db512021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258255https://doaj.org/toc/1932-6203This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participants were selected randomly among primary health care center attendees in Palestine between November 1, 2020 and December 31, 2020. All serum samples were tested for total antibodies using an enzyme-linked immunosorbent assay (ELISA) test. IgM, IgG, and IgA-specific antibody titers were measured using ELISA. The overall prevalence (with 95% confidence intervals [CIs]) of SARS-CoV-2 total antibodies and specific antibodies were estimated. A multivariate regression model was used to assess the predictive factors for SARS-CoV-2-specific antibodies. The overall seroprevalence of SARS-CoV-2 antibodies was 24·0% (95% CI, 21·7%-26·5%). Seroprevalence was significantly higher among people living in south West Bank (adjusted Odds ratio [aOR], 2·22; 95% CI: 1·58-3·11), people who had COVID-19 symptoms (aOR, 3·92; 95% CI, 2·83-5·43), people with a COVID-19 contact history (aOR, 1·44; 95% CI, 1·03-2·03), patients with hypertension (aOR, 1·57; 95% CI, 1·06-2·33), and non-smokers (aOR, 0·47; 95% CI, 0·31-0·72). A total of 171 blood samples from SARS-CoV-2-positive patients were chosen at random for additional serological testing. Specific IgM, IgG, and IgA antibodies were positive in 14·0% (95% CI, 9·2%-20·2%), 88·3% (82·5%-92·7%), and 42·1% (34·6%-59·9%) of the samples, respectively. SARS-CoV-2 antibodies were common among PHC center attendees and were significantly associated to sex, smoking, and COVID-19 contact history. However, considering that almost three-quarters of this population remains susceptible, maintaining public health measures and encouraging access to immunization is critical in protecting this population.Beesan MaraqaWalid BashaRasha KhayyatAbdul-Rahman Abdul-HadiJurouh JabareenKamal Al-ShakhraMai Al-KailaZaher NazzalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258255 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beesan Maraqa Walid Basha Rasha Khayyat Abdul-Rahman Abdul-Hadi Jurouh Jabareen Kamal Al-Shakhra Mai Al-Kaila Zaher Nazzal Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
description	This study aimed to assess the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) total antibodies in the north, middle, and south regions of West Bank and the prevalence of SARS-CoV-2 specific antibodies (IgA, IgM, and IgG) in the Palestinian population. This was a cross-sectional study. The serological and epidemiological data of 1269 persons were assessed. Participants were selected randomly among primary health care center attendees in Palestine between November 1, 2020 and December 31, 2020. All serum samples were tested for total antibodies using an enzyme-linked immunosorbent assay (ELISA) test. IgM, IgG, and IgA-specific antibody titers were measured using ELISA. The overall prevalence (with 95% confidence intervals [CIs]) of SARS-CoV-2 total antibodies and specific antibodies were estimated. A multivariate regression model was used to assess the predictive factors for SARS-CoV-2-specific antibodies. The overall seroprevalence of SARS-CoV-2 antibodies was 24·0% (95% CI, 21·7%-26·5%). Seroprevalence was significantly higher among people living in south West Bank (adjusted Odds ratio [aOR], 2·22; 95% CI: 1·58-3·11), people who had COVID-19 symptoms (aOR, 3·92; 95% CI, 2·83-5·43), people with a COVID-19 contact history (aOR, 1·44; 95% CI, 1·03-2·03), patients with hypertension (aOR, 1·57; 95% CI, 1·06-2·33), and non-smokers (aOR, 0·47; 95% CI, 0·31-0·72). A total of 171 blood samples from SARS-CoV-2-positive patients were chosen at random for additional serological testing. Specific IgM, IgG, and IgA antibodies were positive in 14·0% (95% CI, 9·2%-20·2%), 88·3% (82·5%-92·7%), and 42·1% (34·6%-59·9%) of the samples, respectively. SARS-CoV-2 antibodies were common among PHC center attendees and were significantly associated to sex, smoking, and COVID-19 contact history. However, considering that almost three-quarters of this population remains susceptible, maintaining public health measures and encouraging access to immunization is critical in protecting this population.
format	article
author	Beesan Maraqa Walid Basha Rasha Khayyat Abdul-Rahman Abdul-Hadi Jurouh Jabareen Kamal Al-Shakhra Mai Al-Kaila Zaher Nazzal
author_facet	Beesan Maraqa Walid Basha Rasha Khayyat Abdul-Rahman Abdul-Hadi Jurouh Jabareen Kamal Al-Shakhra Mai Al-Kaila Zaher Nazzal
author_sort	Beesan Maraqa
title	Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
title_short	Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
title_full	Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
title_fullStr	Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
title_full_unstemmed	Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.
title_sort	prevalence of sars-cov-2 antibodies in the palestinian population: a primary health center-based cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3d694a84060440f0bacd9d72e291db51
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Prevalence of SARS-CoV-2 antibodies in the Palestinian population: A primary health center-based cross-sectional study.

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