LRP6 acts as a scaffold protein in cardiac gap junction assembly

LRP6 acts as a scaffold protein in cardiac gap junction assembly

LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.

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Detalles Bibliográficos
Autores principales: Jun Li, Changming Li, Dandan Liang, Fei Lv, Tianyou Yuan, Erlinda The, Xiue Ma, Yahan Wu, Lixiao Zhen, Duanyang Xie, Shiyi Wang, Yuan Liu, Jian Huang, Jingyi Shi, Yi Liu, Dan Shi, Liang Xu, Li Lin, Luying Peng, Jianmin Cui, Weidong Zhu, Yi-Han Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b
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Descripción
Sumario:LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.

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