LRP6 acts as a scaffold protein in cardiac gap junction assembly
LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.
Guardado en:
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:3d69ba0f92e245829107ceca26c0d92b |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:3d69ba0f92e245829107ceca26c0d92b2021-12-02T14:38:56ZLRP6 acts as a scaffold protein in cardiac gap junction assembly10.1038/ncomms117752041-1723https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11775https://doaj.org/toc/2041-1723LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.Jun LiChangming LiDandan LiangFei LvTianyou YuanErlinda TheXiue MaYahan WuLixiao ZhenDuanyang XieShiyi WangYuan LiuJian HuangJingyi ShiYi LiuDan ShiLiang XuLi LinLuying PengJianmin CuiWeidong ZhuYi-Han ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Jun Li Changming Li Dandan Liang Fei Lv Tianyou Yuan Erlinda The Xiue Ma Yahan Wu Lixiao Zhen Duanyang Xie Shiyi Wang Yuan Liu Jian Huang Jingyi Shi Yi Liu Dan Shi Liang Xu Li Lin Luying Peng Jianmin Cui Weidong Zhu Yi-Han Chen LRP6 acts as a scaffold protein in cardiac gap junction assembly |
description |
LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts. |
format |
article |
author |
Jun Li Changming Li Dandan Liang Fei Lv Tianyou Yuan Erlinda The Xiue Ma Yahan Wu Lixiao Zhen Duanyang Xie Shiyi Wang Yuan Liu Jian Huang Jingyi Shi Yi Liu Dan Shi Liang Xu Li Lin Luying Peng Jianmin Cui Weidong Zhu Yi-Han Chen |
author_facet |
Jun Li Changming Li Dandan Liang Fei Lv Tianyou Yuan Erlinda The Xiue Ma Yahan Wu Lixiao Zhen Duanyang Xie Shiyi Wang Yuan Liu Jian Huang Jingyi Shi Yi Liu Dan Shi Liang Xu Li Lin Luying Peng Jianmin Cui Weidong Zhu Yi-Han Chen |
author_sort |
Jun Li |
title |
LRP6 acts as a scaffold protein in cardiac gap junction assembly |
title_short |
LRP6 acts as a scaffold protein in cardiac gap junction assembly |
title_full |
LRP6 acts as a scaffold protein in cardiac gap junction assembly |
title_fullStr |
LRP6 acts as a scaffold protein in cardiac gap junction assembly |
title_full_unstemmed |
LRP6 acts as a scaffold protein in cardiac gap junction assembly |
title_sort |
lrp6 acts as a scaffold protein in cardiac gap junction assembly |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b |
work_keys_str_mv |
AT junli lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT changmingli lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT dandanliang lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT feilv lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT tianyouyuan lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT erlindathe lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT xiuema lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT yahanwu lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT lixiaozhen lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT duanyangxie lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT shiyiwang lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT yuanliu lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT jianhuang lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT jingyishi lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT yiliu lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT danshi lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT liangxu lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT lilin lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT luyingpeng lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT jianmincui lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT weidongzhu lrp6actsasascaffoldproteinincardiacgapjunctionassembly AT yihanchen lrp6actsasascaffoldproteinincardiacgapjunctionassembly |
_version_ |
1718390766697447424 |