LRP6 acts as a scaffold protein in cardiac gap junction assembly

LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.

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Autores principales: Jun Li, Changming Li, Dandan Liang, Fei Lv, Tianyou Yuan, Erlinda The, Xiue Ma, Yahan Wu, Lixiao Zhen, Duanyang Xie, Shiyi Wang, Yuan Liu, Jian Huang, Jingyi Shi, Yi Liu, Dan Shi, Liang Xu, Li Lin, Luying Peng, Jianmin Cui, Weidong Zhu, Yi-Han Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b
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spelling oai:doaj.org-article:3d69ba0f92e245829107ceca26c0d92b2021-12-02T14:38:56ZLRP6 acts as a scaffold protein in cardiac gap junction assembly10.1038/ncomms117752041-1723https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11775https://doaj.org/toc/2041-1723LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.Jun LiChangming LiDandan LiangFei LvTianyou YuanErlinda TheXiue MaYahan WuLixiao ZhenDuanyang XieShiyi WangYuan LiuJian HuangJingyi ShiYi LiuDan ShiLiang XuLi LinLuying PengJianmin CuiWeidong ZhuYi-Han ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Li
Changming Li
Dandan Liang
Fei Lv
Tianyou Yuan
Erlinda The
Xiue Ma
Yahan Wu
Lixiao Zhen
Duanyang Xie
Shiyi Wang
Yuan Liu
Jian Huang
Jingyi Shi
Yi Liu
Dan Shi
Liang Xu
Li Lin
Luying Peng
Jianmin Cui
Weidong Zhu
Yi-Han Chen
LRP6 acts as a scaffold protein in cardiac gap junction assembly
description LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.
format article
author Jun Li
Changming Li
Dandan Liang
Fei Lv
Tianyou Yuan
Erlinda The
Xiue Ma
Yahan Wu
Lixiao Zhen
Duanyang Xie
Shiyi Wang
Yuan Liu
Jian Huang
Jingyi Shi
Yi Liu
Dan Shi
Liang Xu
Li Lin
Luying Peng
Jianmin Cui
Weidong Zhu
Yi-Han Chen
author_facet Jun Li
Changming Li
Dandan Liang
Fei Lv
Tianyou Yuan
Erlinda The
Xiue Ma
Yahan Wu
Lixiao Zhen
Duanyang Xie
Shiyi Wang
Yuan Liu
Jian Huang
Jingyi Shi
Yi Liu
Dan Shi
Liang Xu
Li Lin
Luying Peng
Jianmin Cui
Weidong Zhu
Yi-Han Chen
author_sort Jun Li
title LRP6 acts as a scaffold protein in cardiac gap junction assembly
title_short LRP6 acts as a scaffold protein in cardiac gap junction assembly
title_full LRP6 acts as a scaffold protein in cardiac gap junction assembly
title_fullStr LRP6 acts as a scaffold protein in cardiac gap junction assembly
title_full_unstemmed LRP6 acts as a scaffold protein in cardiac gap junction assembly
title_sort lrp6 acts as a scaffold protein in cardiac gap junction assembly
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3d69ba0f92e245829107ceca26c0d92b
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