Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran

Abstract Risk factors for clinical outcomes of COVID-19 pneumonia have not yet been well established in patients with underlying liver diseases. Our study aimed to describe the clinical characteristics and outcomes of COVID-19 infection among patients with underlying liver diseases and determine the...

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Autores principales:	Mansour Bahardoust, Mohammad Heiat, Mehrdad Khodabandeh, Ashraf Karbasi, Zahra Bagheri-Hosseinabadi, Mohammad Hossein Ataee, Narjes Seidalian, Amirhossein Babazadeh, Shahram Agah, Mohammad Ali Abyazi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d6c85ce52f845918dd8b523bd8a8a1a
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spelling	oai:doaj.org-article:3d6c85ce52f845918dd8b523bd8a8a1a2021-12-02T14:06:19ZPredictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran10.1038/s41598-021-82721-32045-2322https://doaj.org/article/3d6c85ce52f845918dd8b523bd8a8a1a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82721-3https://doaj.org/toc/2045-2322Abstract Risk factors for clinical outcomes of COVID-19 pneumonia have not yet been well established in patients with underlying liver diseases. Our study aimed to describe the clinical characteristics and outcomes of COVID-19 infection among patients with underlying liver diseases and determine the risk factors for severe COVID-19 among them. In a retrospective analytical study, 1002 patients with confirmed COVID-19 pneumonia were divided into two groups: patients with and without underlying liver diseases. The admission period was from 5 March to 14 May 2020. The prevalence of underlying conditions, Demographic data, clinical parameters, laboratory data, and participants' outcomes were evaluated. Logistic regression was used to estimate the predictive factors. Eighty-one (8%) of patients had underlying liver diseases. The frequencies of gastrointestinal symptoms such as diarrhea and vomiting were significantly higher among patients with liver diseases (48% vs. 25% and 46.1% vs. 30% respectively, both P < 0.05). Moreover, ALT and AST were significantly higher among patients with liver diseases (54.5 ± 45.6 vs. 37.1 ± 28.4, P = 0.013 and 41.4 ± 27.2 vs. 29.2 ± 24.3, P = 0.028, respectively). Additionally, the mortality rate was significantly high in patients with liver disease (12.4% vs. 7%, P = 0.018). We also observed that the parameters such as neutrophil to leukocyte ratio [Odds Ratio Adjusted (ORAdj) 1.81, 95% CI 1.21–3.11, P = 0.011] and blood group A (ORAdj 1.59, 95% CI 1.15–2.11, P = 0.001) were associated with progression of symptoms of COVID-19. The presence of underlying liver diseases should be considered one of the poor prognostic factors for worse outcomes in patients with COVID-19.Mansour BahardoustMohammad HeiatMehrdad KhodabandehAshraf KarbasiZahra Bagheri-HosseinabadiMohammad Hossein AtaeeNarjes SeidalianAmirhossein BabazadehShahram AgahMohammad Ali AbyaziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mansour Bahardoust Mohammad Heiat Mehrdad Khodabandeh Ashraf Karbasi Zahra Bagheri-Hosseinabadi Mohammad Hossein Ataee Narjes Seidalian Amirhossein Babazadeh Shahram Agah Mohammad Ali Abyazi Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
description	Abstract Risk factors for clinical outcomes of COVID-19 pneumonia have not yet been well established in patients with underlying liver diseases. Our study aimed to describe the clinical characteristics and outcomes of COVID-19 infection among patients with underlying liver diseases and determine the risk factors for severe COVID-19 among them. In a retrospective analytical study, 1002 patients with confirmed COVID-19 pneumonia were divided into two groups: patients with and without underlying liver diseases. The admission period was from 5 March to 14 May 2020. The prevalence of underlying conditions, Demographic data, clinical parameters, laboratory data, and participants' outcomes were evaluated. Logistic regression was used to estimate the predictive factors. Eighty-one (8%) of patients had underlying liver diseases. The frequencies of gastrointestinal symptoms such as diarrhea and vomiting were significantly higher among patients with liver diseases (48% vs. 25% and 46.1% vs. 30% respectively, both P < 0.05). Moreover, ALT and AST were significantly higher among patients with liver diseases (54.5 ± 45.6 vs. 37.1 ± 28.4, P = 0.013 and 41.4 ± 27.2 vs. 29.2 ± 24.3, P = 0.028, respectively). Additionally, the mortality rate was significantly high in patients with liver disease (12.4% vs. 7%, P = 0.018). We also observed that the parameters such as neutrophil to leukocyte ratio [Odds Ratio Adjusted (ORAdj) 1.81, 95% CI 1.21–3.11, P = 0.011] and blood group A (ORAdj 1.59, 95% CI 1.15–2.11, P = 0.001) were associated with progression of symptoms of COVID-19. The presence of underlying liver diseases should be considered one of the poor prognostic factors for worse outcomes in patients with COVID-19.
format	article
author	Mansour Bahardoust Mohammad Heiat Mehrdad Khodabandeh Ashraf Karbasi Zahra Bagheri-Hosseinabadi Mohammad Hossein Ataee Narjes Seidalian Amirhossein Babazadeh Shahram Agah Mohammad Ali Abyazi
author_facet	Mansour Bahardoust Mohammad Heiat Mehrdad Khodabandeh Ashraf Karbasi Zahra Bagheri-Hosseinabadi Mohammad Hossein Ataee Narjes Seidalian Amirhossein Babazadeh Shahram Agah Mohammad Ali Abyazi
author_sort	Mansour Bahardoust
title	Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
title_short	Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
title_full	Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
title_fullStr	Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
title_full_unstemmed	Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran
title_sort	predictors for the severe coronavirus disease 2019 (covid-19) infection in patients with underlying liver disease: a retrospective analytical study in iran
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3d6c85ce52f845918dd8b523bd8a8a1a
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Predictors for the severe coronavirus disease 2019 (COVID-19) infection in patients with underlying liver disease: a retrospective analytical study in Iran

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