The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis
PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex.
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Nature Portfolio
2017
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oai:doaj.org-article:3d6ffc8f89924108bb617e1a5c7fc6ea2021-12-02T17:06:18ZThe HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis10.1038/s41467-017-01807-72041-1723https://doaj.org/article/3d6ffc8f89924108bb617e1a5c7fc6ea2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01807-7https://doaj.org/toc/2041-1723PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex.Mitsuaki FujimotoRyosuke TakiiEiichi TakakiArpit KatiyarRyuichiro NakatoKatsuhiko ShirahigeAkira NakaiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mitsuaki Fujimoto Ryosuke Takii Eiichi Takaki Arpit Katiyar Ryuichiro Nakato Katsuhiko Shirahige Akira Nakai The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| description |
PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex. |
| format |
article |
| author |
Mitsuaki Fujimoto Ryosuke Takii Eiichi Takaki Arpit Katiyar Ryuichiro Nakato Katsuhiko Shirahige Akira Nakai |
| author_facet |
Mitsuaki Fujimoto Ryosuke Takii Eiichi Takaki Arpit Katiyar Ryuichiro Nakato Katsuhiko Shirahige Akira Nakai |
| author_sort |
Mitsuaki Fujimoto |
| title |
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| title_short |
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| title_full |
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| title_fullStr |
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| title_full_unstemmed |
The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis |
| title_sort |
hsf1–parp13–parp1 complex facilitates dna repair and promotes mammary tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/3d6ffc8f89924108bb617e1a5c7fc6ea |
| work_keys_str_mv |
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