Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease

Abstract Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hy...

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Autores principales:	Jelena P. Seferovic, Milorad Tesic, Petar M. Seferovic, Katarina Lalic, Aleksandra Jotic, Tor Biering-Sørensen, Vojislav Giga, Sanja Stankovic, Natasa Milic, Ljiljana Lukic, Tanja Milicic, Marija Macesic, Jelena Stanarcic Gajovic, Nebojsa M. Lalic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d701813a3804b46be9b56bf38ed9d77
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spelling	oai:doaj.org-article:3d701813a3804b46be9b56bf38ed9d772021-12-02T15:08:02ZIncreased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease10.1038/s41598-018-19229-w2045-2322https://doaj.org/article/3d701813a3804b46be9b56bf38ed9d772018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19229-whttps://doaj.org/toc/2045-2322Abstract Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients with both had highest LVMI, followed by patients with only T2DM or HTN. Study population included 101 T2DM patients, 62 patients with HTN and no T2DM, and 76 patients with T2DM and HTN, excluded for ischemic heart disease. Demographic and clinical data, biochemical measurements, stress echocardiography, transthoracic 2D Doppler and tissue Doppler echocardiography were performed. Multivariable logistic regression was used to determine the independent association with T2DM. Linear regression models and Pearson’s correlation were used to assess the correlations between LVMI and other parameters. Patients with only T2DM had significantly greater LVMI (84.9 ± 20.3 g/m2) compared to patients with T2DM and HTN (77.9 ± 16 g/m2) and only HTN (69.8 ± 12.4 g/m2). In multivariate logistic regression analysis, T2DM was associated with LVMI (OR 1.033, 95%CI 1.003–1.065, p = 0.029). A positive correlation of LVMI was found with fasting glucose (p < 0.001) and HbA1c (p = 0.0003). Increased LVMI could be a potential, pre-symptomatic marker of myocardial structural change in T2DM.Jelena P. SeferovicMilorad TesicPetar M. SeferovicKatarina LalicAleksandra JoticTor Biering-SørensenVojislav GigaSanja StankovicNatasa MilicLjiljana LukicTanja MilicicMarija MacesicJelena Stanarcic GajovicNebojsa M. LalicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jelena P. Seferovic Milorad Tesic Petar M. Seferovic Katarina Lalic Aleksandra Jotic Tor Biering-Sørensen Vojislav Giga Sanja Stankovic Natasa Milic Ljiljana Lukic Tanja Milicic Marija Macesic Jelena Stanarcic Gajovic Nebojsa M. Lalic Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
description	Abstract Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients with both had highest LVMI, followed by patients with only T2DM or HTN. Study population included 101 T2DM patients, 62 patients with HTN and no T2DM, and 76 patients with T2DM and HTN, excluded for ischemic heart disease. Demographic and clinical data, biochemical measurements, stress echocardiography, transthoracic 2D Doppler and tissue Doppler echocardiography were performed. Multivariable logistic regression was used to determine the independent association with T2DM. Linear regression models and Pearson’s correlation were used to assess the correlations between LVMI and other parameters. Patients with only T2DM had significantly greater LVMI (84.9 ± 20.3 g/m2) compared to patients with T2DM and HTN (77.9 ± 16 g/m2) and only HTN (69.8 ± 12.4 g/m2). In multivariate logistic regression analysis, T2DM was associated with LVMI (OR 1.033, 95%CI 1.003–1.065, p = 0.029). A positive correlation of LVMI was found with fasting glucose (p < 0.001) and HbA1c (p = 0.0003). Increased LVMI could be a potential, pre-symptomatic marker of myocardial structural change in T2DM.
format	article
author	Jelena P. Seferovic Milorad Tesic Petar M. Seferovic Katarina Lalic Aleksandra Jotic Tor Biering-Sørensen Vojislav Giga Sanja Stankovic Natasa Milic Ljiljana Lukic Tanja Milicic Marija Macesic Jelena Stanarcic Gajovic Nebojsa M. Lalic
author_facet	Jelena P. Seferovic Milorad Tesic Petar M. Seferovic Katarina Lalic Aleksandra Jotic Tor Biering-Sørensen Vojislav Giga Sanja Stankovic Natasa Milic Ljiljana Lukic Tanja Milicic Marija Macesic Jelena Stanarcic Gajovic Nebojsa M. Lalic
author_sort	Jelena P. Seferovic
title	Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
title_short	Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
title_full	Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
title_fullStr	Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
title_full_unstemmed	Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
title_sort	increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3d701813a3804b46be9b56bf38ed9d77
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Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease

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