Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance

Abstract The clinical importance of serum hepcidin in non-dialysis chronic kidney disease (CKD) patients is unclear. The database of a large-scale multicentre prospective study in Korea of 2238 patients enrolled from 2011–2016 was analysed. After excluding patients with missing serum hepcidin (n = 1...

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Autores principales:	Sung Woo Lee, Jeong Min Kim, Hye Jin Lim, Young-Hwan Hwang, Soo Wan Kim, Wookyung Chung, Kook-Hwan Oh, Curie Ahn, Kyu-Beck Lee, Su Ah Sung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d717bc6342a4e6d9e2a4e6bb303b213
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spelling	oai:doaj.org-article:3d717bc6342a4e6d9e2a4e6bb303b2132021-12-02T16:06:45ZSerum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance10.1038/s41598-017-04664-y2045-2322https://doaj.org/article/3d717bc6342a4e6d9e2a4e6bb303b2132017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04664-yhttps://doaj.org/toc/2045-2322Abstract The clinical importance of serum hepcidin in non-dialysis chronic kidney disease (CKD) patients is unclear. The database of a large-scale multicentre prospective study in Korea of 2238 patients enrolled from 2011–2016 was analysed. After excluding patients with missing serum hepcidin (n = 125) and haemoglobin (n = 23) levels, the study included 2090 non-dialysis CKD patients. Markers of inflammation and iron status were positively associated with serum hepcidin level, regardless of CKD stage. However, estimated glomerular filtration rate was inversely associated with serum hepcidin level, particularly in patients with CKD stages 3b–5 but not in those with CKD stages 1–3a. Use of erythropoiesis-stimulating agents was associated with increased serum hepcidin levels, particularly in patients with CKD stages 3b–5 but not in those with CKD stages 1–3a, and serum hepcidin levels positively correlated with the dose of erythropoiesis-stimulating agent. These findings suggest that serum hepcidin may be a uremic toxin and play an important role in erythropoietin resistance. However, future prospective studies are needed to confirm our results.Sung Woo LeeJeong Min KimHye Jin LimYoung-Hwan HwangSoo Wan KimWookyung ChungKook-Hwan OhCurie AhnKyu-Beck LeeSu Ah SungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung Woo Lee Jeong Min Kim Hye Jin Lim Young-Hwan Hwang Soo Wan Kim Wookyung Chung Kook-Hwan Oh Curie Ahn Kyu-Beck Lee Su Ah Sung Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
description	Abstract The clinical importance of serum hepcidin in non-dialysis chronic kidney disease (CKD) patients is unclear. The database of a large-scale multicentre prospective study in Korea of 2238 patients enrolled from 2011–2016 was analysed. After excluding patients with missing serum hepcidin (n = 125) and haemoglobin (n = 23) levels, the study included 2090 non-dialysis CKD patients. Markers of inflammation and iron status were positively associated with serum hepcidin level, regardless of CKD stage. However, estimated glomerular filtration rate was inversely associated with serum hepcidin level, particularly in patients with CKD stages 3b–5 but not in those with CKD stages 1–3a. Use of erythropoiesis-stimulating agents was associated with increased serum hepcidin levels, particularly in patients with CKD stages 3b–5 but not in those with CKD stages 1–3a, and serum hepcidin levels positively correlated with the dose of erythropoiesis-stimulating agent. These findings suggest that serum hepcidin may be a uremic toxin and play an important role in erythropoietin resistance. However, future prospective studies are needed to confirm our results.
format	article
author	Sung Woo Lee Jeong Min Kim Hye Jin Lim Young-Hwan Hwang Soo Wan Kim Wookyung Chung Kook-Hwan Oh Curie Ahn Kyu-Beck Lee Su Ah Sung
author_facet	Sung Woo Lee Jeong Min Kim Hye Jin Lim Young-Hwan Hwang Soo Wan Kim Wookyung Chung Kook-Hwan Oh Curie Ahn Kyu-Beck Lee Su Ah Sung
author_sort	Sung Woo Lee
title	Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
title_short	Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
title_full	Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
title_fullStr	Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
title_full_unstemmed	Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
title_sort	serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d717bc6342a4e6d9e2a4e6bb303b213
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Serum hepcidin may be a novel uremic toxin, which might be related to erythropoietin resistance

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