HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk

Abstract Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined. To learn more about biological pathways that are...

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Autores principales:	Sanket Kumar Shukla, Weijing Liu, Kunal Sikder, Sankar Addya, Amrita Sarkar, Yidong Wei, Khadija Rafiq
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d7916d403ad485ea2d773875879bd51
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spelling	oai:doaj.org-article:3d7916d403ad485ea2d773875879bd512021-12-02T12:30:43ZHMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk10.1038/s41598-017-04469-z2045-2322https://doaj.org/article/3d7916d403ad485ea2d773875879bd512017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04469-zhttps://doaj.org/toc/2045-2322Abstract Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined. To learn more about biological pathways that are potentially involved in T1D with cardiac dysfunction, we sought to identify differentially expressed genes in the T1D heart. Our study used T1D mice with severe hyperglycemia along with significant deficits in echocardiographic measurements. Microarray analysis of heart tissue RNA revealed that the T1D mice differentially expressed 10 genes compared to control. Using Ingenuity Pathway Analysis (IPA), we showed that these genes were significantly involved in ketogenesis, cardiovascular disease, apoptosis and other toxicology functions. Of these 10 genes, the 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2) was the highest upregulated gene in T1D heart. IPA analysis showed that HMGCS2 was center to many biological networks and pathways. Our data also suggested that apart from heart, the expression of HMGCS2 was also different in kidney and spleen between control and STZ treated mice. In conclusion, The HMGCS2 molecule may potentially be involved in T1D induced cardiac dysfunction.Sanket Kumar ShuklaWeijing LiuKunal SikderSankar AddyaAmrita SarkarYidong WeiKhadija RafiqNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanket Kumar Shukla Weijing Liu Kunal Sikder Sankar Addya Amrita Sarkar Yidong Wei Khadija Rafiq HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
description	Abstract Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined. To learn more about biological pathways that are potentially involved in T1D with cardiac dysfunction, we sought to identify differentially expressed genes in the T1D heart. Our study used T1D mice with severe hyperglycemia along with significant deficits in echocardiographic measurements. Microarray analysis of heart tissue RNA revealed that the T1D mice differentially expressed 10 genes compared to control. Using Ingenuity Pathway Analysis (IPA), we showed that these genes were significantly involved in ketogenesis, cardiovascular disease, apoptosis and other toxicology functions. Of these 10 genes, the 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 (HMGCS2) was the highest upregulated gene in T1D heart. IPA analysis showed that HMGCS2 was center to many biological networks and pathways. Our data also suggested that apart from heart, the expression of HMGCS2 was also different in kidney and spleen between control and STZ treated mice. In conclusion, The HMGCS2 molecule may potentially be involved in T1D induced cardiac dysfunction.
format	article
author	Sanket Kumar Shukla Weijing Liu Kunal Sikder Sankar Addya Amrita Sarkar Yidong Wei Khadija Rafiq
author_facet	Sanket Kumar Shukla Weijing Liu Kunal Sikder Sankar Addya Amrita Sarkar Yidong Wei Khadija Rafiq
author_sort	Sanket Kumar Shukla
title	HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
title_short	HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
title_full	HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
title_fullStr	HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
title_full_unstemmed	HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
title_sort	hmgcs2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d7916d403ad485ea2d773875879bd51
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HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk

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