Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.

<h4>Purpose</h4>Most small renal cell carcinomas (small RCCs) will remain indolent after detection, but some stage I RCCs still metastasize. There are no risk-stratification imaging factors that could be used to identify poor-prognosis patients based on genomic profiling. Here, we evalua...

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Autores principales:	Seiichiro Takao, Yasuhiro Ushijima, Yushi Motomura, Katsumi Sakamoto, Masakazu Hirakawa, Akihiro Nishie, Koshi Mimori, Yasuo Yamashita, Takashi Tsutsumi, Kousei Ishigami
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d7948ebd7494d74b68c8b64548189f0
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spelling	oai:doaj.org-article:3d7948ebd7494d74b68c8b64548189f02021-12-02T20:08:27ZRadiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.1932-620310.1371/journal.pone.0256471https://doaj.org/article/3d7948ebd7494d74b68c8b64548189f02021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256471https://doaj.org/toc/1932-6203<h4>Purpose</h4>Most small renal cell carcinomas (small RCCs) will remain indolent after detection, but some stage I RCCs still metastasize. There are no risk-stratification imaging factors that could be used to identify poor-prognosis patients based on genomic profiling. Here, we evaluated the relationships between imaging parameters and RNA expressions in small RCC and attempted to identify imaging factors that could be used as effective biomarkers.<h4>Methods</h4>We acquired biopsy specimens of 18 clear cell carcinomas that had undergone perfusion CT (pCT) and MRI between April 2018 and March 2019. We performed RNA sequencing, assessed RNA expressions, and calculated each tumor's cell-cycle progression (CCP) score, which has prognostic value in predicting metastatic progression. We classified the tumors into two groups: clear cell type A (ccA) and type B (ccB). CcA has better survival compared to ccB. We evaluated the following characteristics of each tumor: tumor size, presence of pseudocapsule, and fat. We used the pCT and MRI to measure each tumor's volume transfer constant (Ktrans), rate constant (Kep), extracellular extravascular volume fraction (VE), fractional plasma volume (VP), and apparent diffusion coefficient (ADC). The correlations between these small RCC imaging parameters and the tumor size and RNA expressions were determined.<h4>Results</h4>The tumor size was significantly correlated with Kep and inversely correlated with VE, VP, ADC, and hallmark angiogenesis. The CCP score was significantly inversely correlated with Ktrans and Kep. The ccA tumors tended to show a pseudocapsule on MRI.<h4>Conclusion</h4>Tumor size was correlated with low perfusion, but not with prognostic factors based on genomic profiling. Imaging parameters (e.g., Ktrans and Kep) and tumor characteristics (e.g., pseudocapsule) may enable gene-based risk stratification in small RCC.Seiichiro TakaoYasuhiro UshijimaYushi MotomuraKatsumi SakamotoMasakazu HirakawaAkihiro NishieKoshi MimoriYasuo YamashitaTakashi TsutsumiKousei IshigamiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256471 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seiichiro Takao Yasuhiro Ushijima Yushi Motomura Katsumi Sakamoto Masakazu Hirakawa Akihiro Nishie Koshi Mimori Yasuo Yamashita Takashi Tsutsumi Kousei Ishigami Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
description	<h4>Purpose</h4>Most small renal cell carcinomas (small RCCs) will remain indolent after detection, but some stage I RCCs still metastasize. There are no risk-stratification imaging factors that could be used to identify poor-prognosis patients based on genomic profiling. Here, we evaluated the relationships between imaging parameters and RNA expressions in small RCC and attempted to identify imaging factors that could be used as effective biomarkers.<h4>Methods</h4>We acquired biopsy specimens of 18 clear cell carcinomas that had undergone perfusion CT (pCT) and MRI between April 2018 and March 2019. We performed RNA sequencing, assessed RNA expressions, and calculated each tumor's cell-cycle progression (CCP) score, which has prognostic value in predicting metastatic progression. We classified the tumors into two groups: clear cell type A (ccA) and type B (ccB). CcA has better survival compared to ccB. We evaluated the following characteristics of each tumor: tumor size, presence of pseudocapsule, and fat. We used the pCT and MRI to measure each tumor's volume transfer constant (Ktrans), rate constant (Kep), extracellular extravascular volume fraction (VE), fractional plasma volume (VP), and apparent diffusion coefficient (ADC). The correlations between these small RCC imaging parameters and the tumor size and RNA expressions were determined.<h4>Results</h4>The tumor size was significantly correlated with Kep and inversely correlated with VE, VP, ADC, and hallmark angiogenesis. The CCP score was significantly inversely correlated with Ktrans and Kep. The ccA tumors tended to show a pseudocapsule on MRI.<h4>Conclusion</h4>Tumor size was correlated with low perfusion, but not with prognostic factors based on genomic profiling. Imaging parameters (e.g., Ktrans and Kep) and tumor characteristics (e.g., pseudocapsule) may enable gene-based risk stratification in small RCC.
format	article
author	Seiichiro Takao Yasuhiro Ushijima Yushi Motomura Katsumi Sakamoto Masakazu Hirakawa Akihiro Nishie Koshi Mimori Yasuo Yamashita Takashi Tsutsumi Kousei Ishigami
author_facet	Seiichiro Takao Yasuhiro Ushijima Yushi Motomura Katsumi Sakamoto Masakazu Hirakawa Akihiro Nishie Koshi Mimori Yasuo Yamashita Takashi Tsutsumi Kousei Ishigami
author_sort	Seiichiro Takao
title	Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
title_short	Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
title_full	Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
title_fullStr	Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
title_full_unstemmed	Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.
title_sort	radiology- and gene-based risk stratification in small renal cell carcinoma: a preliminary study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3d7948ebd7494d74b68c8b64548189f0
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Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study.

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