Structural determinants of microtubule minus end preference in CAMSAP CKK domains

CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has a different interaction with, and inability to re...

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Autores principales:	Joseph Atherton, Yanzhang Luo, Shengqi Xiang, Chao Yang, Ankit Rai, Kai Jiang, Marcel Stangier, Annapurna Vemu, Alexander D. Cook, Su Wang, Antonina Roll-Mecak, Michel O. Steinmetz, Anna Akhmanova, Marc Baldus, Carolyn A. Moores
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d87bd15c883481392c7b1e0dbdc5c01
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spelling	oai:doaj.org-article:3d87bd15c883481392c7b1e0dbdc5c012021-12-02T16:58:26ZStructural determinants of microtubule minus end preference in CAMSAP CKK domains10.1038/s41467-019-13247-62041-1723https://doaj.org/article/3d87bd15c883481392c7b1e0dbdc5c012019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13247-6https://doaj.org/toc/2041-1723CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has a different interaction with, and inability to remodel, its MT binding site, shedding light on the CAMSAP/Patronin end binding mechanism.Joseph AthertonYanzhang LuoShengqi XiangChao YangAnkit RaiKai JiangMarcel StangierAnnapurna VemuAlexander D. CookSu WangAntonina Roll-MecakMichel O. SteinmetzAnna AkhmanovaMarc BaldusCarolyn A. MooresNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph Atherton Yanzhang Luo Shengqi Xiang Chao Yang Ankit Rai Kai Jiang Marcel Stangier Annapurna Vemu Alexander D. Cook Su Wang Antonina Roll-Mecak Michel O. Steinmetz Anna Akhmanova Marc Baldus Carolyn A. Moores Structural determinants of microtubule minus end preference in CAMSAP CKK domains
description	CKK domain containing CAMSAP/Patronins recognise and regulate microtubule (MT) minus end dynamics. Here the authors compare cryo-EM structures of MT-bound human CKK and Naegleria gruberi CKK which lacks minus-end binding preference, finding NgCKK has a different interaction with, and inability to remodel, its MT binding site, shedding light on the CAMSAP/Patronin end binding mechanism.
format	article
author	Joseph Atherton Yanzhang Luo Shengqi Xiang Chao Yang Ankit Rai Kai Jiang Marcel Stangier Annapurna Vemu Alexander D. Cook Su Wang Antonina Roll-Mecak Michel O. Steinmetz Anna Akhmanova Marc Baldus Carolyn A. Moores
author_facet	Joseph Atherton Yanzhang Luo Shengqi Xiang Chao Yang Ankit Rai Kai Jiang Marcel Stangier Annapurna Vemu Alexander D. Cook Su Wang Antonina Roll-Mecak Michel O. Steinmetz Anna Akhmanova Marc Baldus Carolyn A. Moores
author_sort	Joseph Atherton
title	Structural determinants of microtubule minus end preference in CAMSAP CKK domains
title_short	Structural determinants of microtubule minus end preference in CAMSAP CKK domains
title_full	Structural determinants of microtubule minus end preference in CAMSAP CKK domains
title_fullStr	Structural determinants of microtubule minus end preference in CAMSAP CKK domains
title_full_unstemmed	Structural determinants of microtubule minus end preference in CAMSAP CKK domains
title_sort	structural determinants of microtubule minus end preference in camsap ckk domains
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3d87bd15c883481392c7b1e0dbdc5c01
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Structural determinants of microtubule minus end preference in CAMSAP CKK domains

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