Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy

Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an inflammatory response are factors contributing to IRI-related damage that can each result in...

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Autores principales:	Yani Wang, Huibin Liu, Na Sun, Jing Li, Xiang Peng, Ying Jia, Jason Karch, Bo Yu, Xander H. T. Wehrens, Jinwei Tian
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/3d8b56a83851437c8c90c12bc75ce989
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spelling	oai:doaj.org-article:3d8b56a83851437c8c90c12bc75ce9892021-11-08T02:36:50ZIrisin: A Promising Target for Ischemia-Reperfusion Injury Therapy1942-099410.1155/2021/5391706https://doaj.org/article/3d8b56a83851437c8c90c12bc75ce9892021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5391706https://doaj.org/toc/1942-0994Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an inflammatory response are factors contributing to IRI-related damage that can each result in cell death. Irisin is a polypeptide that is proteolytically cleaved from the extracellular domain of fibronectin type III domain-containing protein 5 (FNDC5). Irisin acts as a myokine that potentially mediates beneficial effects of exercise by reducing oxidative stress, improving mitochondrial fitness, and suppressing inflammation. The existing literature also suggests a possible link between irisin and IRI, involving mechanisms similar to those associated with exercise. This article will review the pathogenesis of IRI and the potential benefits and current limitations of irisin as a therapeutic strategy for IRI, while highlighting the mechanistic correlations between irisin and IRI.Yani WangHuibin LiuNa SunJing LiXiang PengYing JiaJason KarchBo YuXander H. T. WehrensJinwei TianHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Yani Wang Huibin Liu Na Sun Jing Li Xiang Peng Ying Jia Jason Karch Bo Yu Xander H. T. Wehrens Jinwei Tian Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
description	Ischemia-reperfusion injury (IRI) is defined as the total combined damage that occurs during a period of ischemia and following the recovery of blood flow. Oxidative stress, mitochondrial dysfunction, and an inflammatory response are factors contributing to IRI-related damage that can each result in cell death. Irisin is a polypeptide that is proteolytically cleaved from the extracellular domain of fibronectin type III domain-containing protein 5 (FNDC5). Irisin acts as a myokine that potentially mediates beneficial effects of exercise by reducing oxidative stress, improving mitochondrial fitness, and suppressing inflammation. The existing literature also suggests a possible link between irisin and IRI, involving mechanisms similar to those associated with exercise. This article will review the pathogenesis of IRI and the potential benefits and current limitations of irisin as a therapeutic strategy for IRI, while highlighting the mechanistic correlations between irisin and IRI.
format	article
author	Yani Wang Huibin Liu Na Sun Jing Li Xiang Peng Ying Jia Jason Karch Bo Yu Xander H. T. Wehrens Jinwei Tian
author_facet	Yani Wang Huibin Liu Na Sun Jing Li Xiang Peng Ying Jia Jason Karch Bo Yu Xander H. T. Wehrens Jinwei Tian
author_sort	Yani Wang
title	Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
title_short	Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
title_full	Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
title_fullStr	Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
title_full_unstemmed	Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy
title_sort	irisin: a promising target for ischemia-reperfusion injury therapy
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/3d8b56a83851437c8c90c12bc75ce989
work_keys_str_mv	AT yaniwang irisinapromisingtargetforischemiareperfusioninjurytherapy AT huibinliu irisinapromisingtargetforischemiareperfusioninjurytherapy AT nasun irisinapromisingtargetforischemiareperfusioninjurytherapy AT jingli irisinapromisingtargetforischemiareperfusioninjurytherapy AT xiangpeng irisinapromisingtargetforischemiareperfusioninjurytherapy AT yingjia irisinapromisingtargetforischemiareperfusioninjurytherapy AT jasonkarch irisinapromisingtargetforischemiareperfusioninjurytherapy AT boyu irisinapromisingtargetforischemiareperfusioninjurytherapy AT xanderhtwehrens irisinapromisingtargetforischemiareperfusioninjurytherapy AT jinweitian irisinapromisingtargetforischemiareperfusioninjurytherapy
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Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy

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