Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis

Abstract CD146, also known as melanoma cell adhesion molecule, was initially identified as a marker of melanoma progression and metastasis. Recently many clinical studies investigated overexpression of CD146 predict poor prognosis of solid tumor, however, the results was inconclusive, partly due to...

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Autores principales:	Ping Zeng, Hai Li, Pei-Hua Lu, Li-Na Zhou, Min Tang, Chao-Ying Liu, Min-Bin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3d9180d5f20a43069f422a82c37728da
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spelling	oai:doaj.org-article:3d9180d5f20a43069f422a82c37728da2021-12-02T11:41:00ZPrognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis10.1038/s41598-017-01061-32045-2322https://doaj.org/article/3d9180d5f20a43069f422a82c37728da2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01061-3https://doaj.org/toc/2045-2322Abstract CD146, also known as melanoma cell adhesion molecule, was initially identified as a marker of melanoma progression and metastasis. Recently many clinical studies investigated overexpression of CD146 predict poor prognosis of solid tumor, however, the results was inconclusive, partly due to small numbers of patients included. This present meta-analysis was therefore performed utilizing the results of all clinical studies concerned to determine the prognostic value of CD146 expression in solid tumors. Relevant articles were identified through searching the PubMed, Web of Science and Embase database. In this meta-analysis, 12 studies involving 2,694 participants were included, and we drew the conclusion that strong significant associations between CD146 expression and all endpoints: overall survival (OS) [hazard ratio (HR) = 2.496, 95% confidence interval (95% CI) 2.115–2.946], time to progression (TTP) (HR = 2.445, 95% CI 1.975–3.027). Furthermore, the subgroup analysis revealed that the associations between CD146 overexpression and the outcome endpoints (OS or TTP) were significant in Mongoloid patients and Caucasian patients, as well in patients with lung cancer and digestive system cancer. In conclusion, these results showed that high CD146 was associated with poor survival in human solid tumors. CD146 may be a valuable prognosis predictive biomarker; nevertheless, whether CD146 could be a potential therapeutic target in human solid tumors needs to be further studied.Ping ZengHai LiPei-Hua LuLi-Na ZhouMin TangChao-Ying LiuMin-Bin ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ping Zeng Hai Li Pei-Hua Lu Li-Na Zhou Min Tang Chao-Ying Liu Min-Bin Chen Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
description	Abstract CD146, also known as melanoma cell adhesion molecule, was initially identified as a marker of melanoma progression and metastasis. Recently many clinical studies investigated overexpression of CD146 predict poor prognosis of solid tumor, however, the results was inconclusive, partly due to small numbers of patients included. This present meta-analysis was therefore performed utilizing the results of all clinical studies concerned to determine the prognostic value of CD146 expression in solid tumors. Relevant articles were identified through searching the PubMed, Web of Science and Embase database. In this meta-analysis, 12 studies involving 2,694 participants were included, and we drew the conclusion that strong significant associations between CD146 expression and all endpoints: overall survival (OS) [hazard ratio (HR) = 2.496, 95% confidence interval (95% CI) 2.115–2.946], time to progression (TTP) (HR = 2.445, 95% CI 1.975–3.027). Furthermore, the subgroup analysis revealed that the associations between CD146 overexpression and the outcome endpoints (OS or TTP) were significant in Mongoloid patients and Caucasian patients, as well in patients with lung cancer and digestive system cancer. In conclusion, these results showed that high CD146 was associated with poor survival in human solid tumors. CD146 may be a valuable prognosis predictive biomarker; nevertheless, whether CD146 could be a potential therapeutic target in human solid tumors needs to be further studied.
format	article
author	Ping Zeng Hai Li Pei-Hua Lu Li-Na Zhou Min Tang Chao-Ying Liu Min-Bin Chen
author_facet	Ping Zeng Hai Li Pei-Hua Lu Li-Na Zhou Min Tang Chao-Ying Liu Min-Bin Chen
author_sort	Ping Zeng
title	Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
title_short	Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
title_full	Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
title_fullStr	Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
title_full_unstemmed	Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis
title_sort	prognostic value of cd146 in solid tumor: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3d9180d5f20a43069f422a82c37728da
work_keys_str_mv	AT pingzeng prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT haili prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT peihualu prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT linazhou prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT mintang prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT chaoyingliu prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis AT minbinchen prognosticvalueofcd146insolidtumorasystematicreviewandmetaanalysis
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Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis

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