Single-molecule characterization of extrinsic transcription termination by Sen1 helicase

Yeast’s Sen1 helicase is involved in the suppression of antisense transcription from bidirectional eukaryotic promoters. Here authors develop and utilize a quantitative single-molecule assay reporting on the kinetics of extrinsic eukaryotic transcription termination by the Sen1 helicase and a reacti...

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Autores principales:	S. Wang, Z. Han, D. Libri, O. Porrua, T. R. Strick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d9705c28c024deb97795489176345ef
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spelling	oai:doaj.org-article:3d9705c28c024deb97795489176345ef2021-12-02T17:32:09ZSingle-molecule characterization of extrinsic transcription termination by Sen1 helicase10.1038/s41467-019-09560-92041-1723https://doaj.org/article/3d9705c28c024deb97795489176345ef2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09560-9https://doaj.org/toc/2041-1723Yeast’s Sen1 helicase is involved in the suppression of antisense transcription from bidirectional eukaryotic promoters. Here authors develop and utilize a quantitative single-molecule assay reporting on the kinetics of extrinsic eukaryotic transcription termination by the Sen1 helicase and a reaction intermediate in which the Pol II transcription bubble appears half-rewound.S. WangZ. HanD. LibriO. PorruaT. R. StrickNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Wang Z. Han D. Libri O. Porrua T. R. Strick Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
description	Yeast’s Sen1 helicase is involved in the suppression of antisense transcription from bidirectional eukaryotic promoters. Here authors develop and utilize a quantitative single-molecule assay reporting on the kinetics of extrinsic eukaryotic transcription termination by the Sen1 helicase and a reaction intermediate in which the Pol II transcription bubble appears half-rewound.
format	article
author	S. Wang Z. Han D. Libri O. Porrua T. R. Strick
author_facet	S. Wang Z. Han D. Libri O. Porrua T. R. Strick
author_sort	S. Wang
title	Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
title_short	Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
title_full	Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
title_fullStr	Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
title_full_unstemmed	Single-molecule characterization of extrinsic transcription termination by Sen1 helicase
title_sort	single-molecule characterization of extrinsic transcription termination by sen1 helicase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3d9705c28c024deb97795489176345ef
work_keys_str_mv	AT swang singlemoleculecharacterizationofextrinsictranscriptionterminationbysen1helicase AT zhan singlemoleculecharacterizationofextrinsictranscriptionterminationbysen1helicase AT dlibri singlemoleculecharacterizationofextrinsictranscriptionterminationbysen1helicase AT oporrua singlemoleculecharacterizationofextrinsictranscriptionterminationbysen1helicase AT trstrick singlemoleculecharacterizationofextrinsictranscriptionterminationbysen1helicase
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Single-molecule characterization of extrinsic transcription termination by Sen1 helicase

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