On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches

The human fungal pathogen <i>Candida albicans</i> is a dimorphic opportunistic pathogen that colonises most of the human population without creating any harm. However, this fungus can also cause life-threatening infections in immunocompromised individuals. The ability to successfully col...

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Autores principales:	Elise Iracane, Samuel Vega-Estévez, Alessia Buscaino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Candida albicans</i> epigenetic yeast chromatin biofilm hyphae Medicine R
Acceso en línea:	https://doaj.org/article/3d99d44a303f412984e1bec0a40cc7ea
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spelling	oai:doaj.org-article:3d99d44a303f412984e1bec0a40cc7ea2021-11-25T18:38:26ZOn and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches10.3390/pathogens101114632076-0817https://doaj.org/article/3d99d44a303f412984e1bec0a40cc7ea2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1463https://doaj.org/toc/2076-0817The human fungal pathogen <i>Candida albicans</i> is a dimorphic opportunistic pathogen that colonises most of the human population without creating any harm. However, this fungus can also cause life-threatening infections in immunocompromised individuals. The ability to successfully colonise different host niches is critical for establishing infections and pathogenesis. <i>C. albicans</i> can live and divide in various morphological forms critical for its survival in the host. Indeed, <i>C. albicans</i> can grow as both yeast and hyphae and can form biofilms containing hyphae. The transcriptional regulatory network governing the switching between these different forms is complex but well understood. In contrast, non-DNA based epigenetic modulation is emerging as a crucial but still poorly studied regulatory mechanism of morphological transition. This review explores our current understanding of chromatin-mediated epigenetic regulation of the yeast to hyphae switch and biofilm formation. We highlight how modification of chromatin structure and non-coding RNAs contribute to these morphological transitions.Elise IracaneSamuel Vega-EstévezAlessia BuscainoMDPI AGarticle<i>Candida albicans</i>epigeneticyeastchromatinbiofilmhyphaeMedicineRENPathogens, Vol 10, Iss 1463, p 1463 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Candida albicans</i> epigenetic yeast chromatin biofilm hyphae Medicine R
spellingShingle	<i>Candida albicans</i> epigenetic yeast chromatin biofilm hyphae Medicine R Elise Iracane Samuel Vega-Estévez Alessia Buscaino On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
description	The human fungal pathogen <i>Candida albicans</i> is a dimorphic opportunistic pathogen that colonises most of the human population without creating any harm. However, this fungus can also cause life-threatening infections in immunocompromised individuals. The ability to successfully colonise different host niches is critical for establishing infections and pathogenesis. <i>C. albicans</i> can live and divide in various morphological forms critical for its survival in the host. Indeed, <i>C. albicans</i> can grow as both yeast and hyphae and can form biofilms containing hyphae. The transcriptional regulatory network governing the switching between these different forms is complex but well understood. In contrast, non-DNA based epigenetic modulation is emerging as a crucial but still poorly studied regulatory mechanism of morphological transition. This review explores our current understanding of chromatin-mediated epigenetic regulation of the yeast to hyphae switch and biofilm formation. We highlight how modification of chromatin structure and non-coding RNAs contribute to these morphological transitions.
format	article
author	Elise Iracane Samuel Vega-Estévez Alessia Buscaino
author_facet	Elise Iracane Samuel Vega-Estévez Alessia Buscaino
author_sort	Elise Iracane
title	On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
title_short	On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
title_full	On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
title_fullStr	On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
title_full_unstemmed	On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches
title_sort	on and off: epigenetic regulation of <i>c. albicans</i> morphological switches
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3d99d44a303f412984e1bec0a40cc7ea
work_keys_str_mv	AT eliseiracane onandoffepigeneticregulationoficalbicansimorphologicalswitches AT samuelvegaestevez onandoffepigeneticregulationoficalbicansimorphologicalswitches AT alessiabuscaino onandoffepigeneticregulationoficalbicansimorphologicalswitches
_version_	1718410887897808896

On and Off: Epigenetic Regulation of <i>C. albicans</i> Morphological Switches

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