A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan
Koji Tsuruga,1 Norio Sugawara,1 Norio Yasui-Furukori,1 Ippei Takahashi,2 Shoko Tsuchimine,1 Ayako Kaneda,1 Shigeyuki Nakaji,2 Kazuhiko Nakamura1 1Department of Neuropsychiatry, 2Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: Amyloid bet...
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Dove Medical Press
2014
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oai:doaj.org-article:3d9ad54209274f8db3e4af3b764a79802021-12-02T00:29:48ZA positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan1178-2021https://doaj.org/article/3d9ad54209274f8db3e4af3b764a79802014-08-01T00:00:00Zhttp://www.dovepress.com/a-positive-correlation-between-serum-amyloid-beta-levels-and-depressiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Koji Tsuruga,1 Norio Sugawara,1 Norio Yasui-Furukori,1 Ippei Takahashi,2 Shoko Tsuchimine,1 Ayako Kaneda,1 Shigeyuki Nakaji,2 Kazuhiko Nakamura1 1Department of Neuropsychiatry, 2Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: Amyloid beta (Aβ) levels have been associated with an increased risk of Alzheimer’s disease (AD). As depression is common before the onset of AD, serum Aß levels could be associated with depressive symptoms. The aim of this study was to investigate whether serum Aβ levels are associated with depressive symptoms and/or cognitive function in community-dwelling elderly individuals. Methods: We examined the association between serum Aβ levels and depression among 419 Japanese community-dwelling elderly individuals aged 60 years and over. Subjects were divided into two subgroups: younger elderly between 60 and 69 years old and older elderly over 69 years old. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and symptoms of depression were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The ability to perform activities of daily living was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Serum Aβ levels were measured with a human amyloid beta enzyme-linked immunosorbent assay kit. Results: After controlling for potential confounding variables, a multiple linear regression analysis showed that increased levels of serum Aβ40 and Aβ42 were associated with higher CES-D scores in the older elderly subgroup. Under the same condition, multiple regression showed that serum Aβ levels were not associated with MMSE scores among the total subjects, younger elderly, or older elderly. Conclusion: Serum Aβ levels were associated with depressive symptoms in community-dwelling elderly individuals. The present study indicates the possibility that serum Aβ may be involved in the development of late-onset depression. Keywords: Alzheimer’s disease, depression, dementia, JapaneseTsuruga KSugawara NYasui-Furukori NTakahashi ITsuchimine SKaneda ANakaji SNakamura KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1621-1627 (2014) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tsuruga K Sugawara N Yasui-Furukori N Takahashi I Tsuchimine S Kaneda A Nakaji S Nakamura K A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| description |
Koji Tsuruga,1 Norio Sugawara,1 Norio Yasui-Furukori,1 Ippei Takahashi,2 Shoko Tsuchimine,1 Ayako Kaneda,1 Shigeyuki Nakaji,2 Kazuhiko Nakamura1 1Department of Neuropsychiatry, 2Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Background: Amyloid beta (Aβ) levels have been associated with an increased risk of Alzheimer’s disease (AD). As depression is common before the onset of AD, serum Aß levels could be associated with depressive symptoms. The aim of this study was to investigate whether serum Aβ levels are associated with depressive symptoms and/or cognitive function in community-dwelling elderly individuals. Methods: We examined the association between serum Aβ levels and depression among 419 Japanese community-dwelling elderly individuals aged 60 years and over. Subjects were divided into two subgroups: younger elderly between 60 and 69 years old and older elderly over 69 years old. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and symptoms of depression were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The ability to perform activities of daily living was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Serum Aβ levels were measured with a human amyloid beta enzyme-linked immunosorbent assay kit. Results: After controlling for potential confounding variables, a multiple linear regression analysis showed that increased levels of serum Aβ40 and Aβ42 were associated with higher CES-D scores in the older elderly subgroup. Under the same condition, multiple regression showed that serum Aβ levels were not associated with MMSE scores among the total subjects, younger elderly, or older elderly. Conclusion: Serum Aβ levels were associated with depressive symptoms in community-dwelling elderly individuals. The present study indicates the possibility that serum Aβ may be involved in the development of late-onset depression. Keywords: Alzheimer’s disease, depression, dementia, Japanese |
| format |
article |
| author |
Tsuruga K Sugawara N Yasui-Furukori N Takahashi I Tsuchimine S Kaneda A Nakaji S Nakamura K |
| author_facet |
Tsuruga K Sugawara N Yasui-Furukori N Takahashi I Tsuchimine S Kaneda A Nakaji S Nakamura K |
| author_sort |
Tsuruga K |
| title |
A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| title_short |
A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| title_full |
A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| title_fullStr |
A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| title_full_unstemmed |
A positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in Japan |
| title_sort |
positive correlation between serum amyloid β levels and depressive symptoms among community-dwelling elderly individuals in japan |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/3d9ad54209274f8db3e4af3b764a7980 |
| work_keys_str_mv |
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