Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis

Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and...

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Autores principales:	Wen-Ching Shen, Yung-Chih Lai, Ling-Hui Li, Kolin Liao, Hung-Chang Lai, Shou-Yen Kao, John Wang, Cheng-Ming Chuong, Shih-Chieh Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d9e1d220af747f7ae789bc2278b8a54
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spelling	oai:doaj.org-article:3d9e1d220af747f7ae789bc2278b8a542021-12-02T17:02:03ZMethylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis10.1038/s41467-019-10197-x2041-1723https://doaj.org/article/3d9e1d220af747f7ae789bc2278b8a542019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10197-xhttps://doaj.org/toc/2041-1723Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and reduces oncogenesis.Wen-Ching ShenYung-Chih LaiLing-Hui LiKolin LiaoHung-Chang LaiShou-Yen KaoJohn WangCheng-Ming ChuongShih-Chieh HungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Ching Shen Yung-Chih Lai Ling-Hui Li Kolin Liao Hung-Chang Lai Shou-Yen Kao John Wang Cheng-Ming Chuong Shih-Chieh Hung Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
description	Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and reduces oncogenesis.
format	article
author	Wen-Ching Shen Yung-Chih Lai Ling-Hui Li Kolin Liao Hung-Chang Lai Shou-Yen Kao John Wang Cheng-Ming Chuong Shih-Chieh Hung
author_facet	Wen-Ching Shen Yung-Chih Lai Ling-Hui Li Kolin Liao Hung-Chang Lai Shou-Yen Kao John Wang Cheng-Ming Chuong Shih-Chieh Hung
author_sort	Wen-Ching Shen
title	Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
title_short	Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
title_full	Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
title_fullStr	Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
title_full_unstemmed	Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
title_sort	methylation and pten activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3d9e1d220af747f7ae789bc2278b8a54
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Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis

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