Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
ABSTRACT Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that i...
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Main Authors: | Jeremiah Athmer, Anthony R. Fehr, Matthew E. Grunewald, Wen Qu, D. Lori Wheeler, Kevin W. Graepel, Rudragouda Channappanavar, Aimee Sekine, Dana Saud Aldabeeb, Michael Gale, Mark R. Denison, Stanley Perlman |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2018
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Online Access: | https://doaj.org/article/3da1a93d54de4efbb6a33718ce452b29 |
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