Wnt pathway activation by ADP-ribosylation

Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt...

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Autores principales:	Eungi Yang, Ofelia Tacchelly-Benites, Zhenghan Wang, Michael P. Randall, Ai Tian, Hassina Benchabane, Sarah Freemantle, Claudio Pikielny, Nicholas S. Tolwinski, Ethan Lee, Yashi Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3da63aa64149454db576577367439463
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spelling	oai:doaj.org-article:3da63aa64149454db5765773674394632021-12-02T15:35:22ZWnt pathway activation by ADP-ribosylation10.1038/ncomms114302041-1723https://doaj.org/article/3da63aa64149454db5765773674394632016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11430https://doaj.org/toc/2041-1723Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt co-receptor LRP6.Eungi YangOfelia Tacchelly-BenitesZhenghan WangMichael P. RandallAi TianHassina BenchabaneSarah FreemantleClaudio PikielnyNicholas S. TolwinskiEthan LeeYashi AhmedNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eungi Yang Ofelia Tacchelly-Benites Zhenghan Wang Michael P. Randall Ai Tian Hassina Benchabane Sarah Freemantle Claudio Pikielny Nicholas S. Tolwinski Ethan Lee Yashi Ahmed Wnt pathway activation by ADP-ribosylation
description	Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt co-receptor LRP6.
format	article
author	Eungi Yang Ofelia Tacchelly-Benites Zhenghan Wang Michael P. Randall Ai Tian Hassina Benchabane Sarah Freemantle Claudio Pikielny Nicholas S. Tolwinski Ethan Lee Yashi Ahmed
author_facet	Eungi Yang Ofelia Tacchelly-Benites Zhenghan Wang Michael P. Randall Ai Tian Hassina Benchabane Sarah Freemantle Claudio Pikielny Nicholas S. Tolwinski Ethan Lee Yashi Ahmed
author_sort	Eungi Yang
title	Wnt pathway activation by ADP-ribosylation
title_short	Wnt pathway activation by ADP-ribosylation
title_full	Wnt pathway activation by ADP-ribosylation
title_fullStr	Wnt pathway activation by ADP-ribosylation
title_full_unstemmed	Wnt pathway activation by ADP-ribosylation
title_sort	wnt pathway activation by adp-ribosylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3da63aa64149454db576577367439463
work_keys_str_mv	AT eungiyang wntpathwayactivationbyadpribosylation AT ofeliatacchellybenites wntpathwayactivationbyadpribosylation AT zhenghanwang wntpathwayactivationbyadpribosylation AT michaelprandall wntpathwayactivationbyadpribosylation AT aitian wntpathwayactivationbyadpribosylation AT hassinabenchabane wntpathwayactivationbyadpribosylation AT sarahfreemantle wntpathwayactivationbyadpribosylation AT claudiopikielny wntpathwayactivationbyadpribosylation AT nicholasstolwinski wntpathwayactivationbyadpribosylation AT ethanlee wntpathwayactivationbyadpribosylation AT yashiahmed wntpathwayactivationbyadpribosylation
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Wnt pathway activation by ADP-ribosylation

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