Synthetic molecular evolution of hybrid cell penetrating peptides

Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs with improved efficiency and lower toxicity.

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Detalles Bibliográficos
Autores principales:	W. Berkeley Kauffman, Shantanu Guha, William C. Wimley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3daa451295c740d1afe35adcf3ac37e6
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spelling	oai:doaj.org-article:3daa451295c740d1afe35adcf3ac37e62021-12-02T15:34:19ZSynthetic molecular evolution of hybrid cell penetrating peptides10.1038/s41467-018-04874-62041-1723https://doaj.org/article/3daa451295c740d1afe35adcf3ac37e62018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04874-6https://doaj.org/toc/2041-1723Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs with improved efficiency and lower toxicity.W. Berkeley KauffmanShantanu GuhaWilliam C. WimleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q W. Berkeley Kauffman Shantanu Guha William C. Wimley Synthetic molecular evolution of hybrid cell penetrating peptides
description	Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs with improved efficiency and lower toxicity.
format	article
author	W. Berkeley Kauffman Shantanu Guha William C. Wimley
author_facet	W. Berkeley Kauffman Shantanu Guha William C. Wimley
author_sort	W. Berkeley Kauffman
title	Synthetic molecular evolution of hybrid cell penetrating peptides
title_short	Synthetic molecular evolution of hybrid cell penetrating peptides
title_full	Synthetic molecular evolution of hybrid cell penetrating peptides
title_fullStr	Synthetic molecular evolution of hybrid cell penetrating peptides
title_full_unstemmed	Synthetic molecular evolution of hybrid cell penetrating peptides
title_sort	synthetic molecular evolution of hybrid cell penetrating peptides
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3daa451295c740d1afe35adcf3ac37e6
work_keys_str_mv	AT wberkeleykauffman syntheticmolecularevolutionofhybridcellpenetratingpeptides AT shantanuguha syntheticmolecularevolutionofhybridcellpenetratingpeptides AT williamcwimley syntheticmolecularevolutionofhybridcellpenetratingpeptides
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Synthetic molecular evolution of hybrid cell penetrating peptides

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