Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series

Yasunari Yamaguchi, Sohei Kimoto, Takeshi Nagahama, Toshifumi Kishimoto Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan Objective: Several studies have documented that treatment with various antidepressant agents can result in mood switching during major depr...

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Autores principales:	Yamaguchi Y, Kimoto S, Nagahama T, Kishimoto T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Selective serotonin reuptake inhibitor (SSRI) escitalopram antidepressant treatment-emergent mania/hypomania dosage-related bipolar depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3daa9ae2d03d4d9dbfc1423f34e786a9
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spelling	oai:doaj.org-article:3daa9ae2d03d4d9dbfc1423f34e786a92021-12-02T02:26:59ZDosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series1178-2021https://doaj.org/article/3daa9ae2d03d4d9dbfc1423f34e786a92018-08-01T00:00:00Zhttps://www.dovepress.com/dosage-related-nature-of-escitalopram-treatment-emergent-maniahypomani-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yasunari Yamaguchi, Sohei Kimoto, Takeshi Nagahama, Toshifumi Kishimoto Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan Objective: Several studies have documented that treatment with various antidepressant agents can result in mood switching during major depressive episodes. Escitalopram, one of the newer selective serotonin reuptake inhibitors (SSRIs), is considered preferable due to its relatively high efficacy and acceptability. Although a few cases of escitalopram treatment-emergent mania have been reported, it remains unknown whether this effect is dose-related.Method: In the present report, we discuss three cases of treatment-emergent mania/hypomania in patients receiving escitalopram for major depressive episodes. No patients had a family or personal history of bipolar disorder.Results: In all three cases, manic or hypomanic symptoms emerged within 1 month right after the dosage of escitalopram was increased to 20 mg/day. Moreover, manic episodes subsided as the dosage of escitalopram was reduced. Mood switching was not observed after the cessation of escitalopram treatment.Conclusion: Our case series indicates that escitalopram may induce treatment-emergent mania/hypomania in a dose-related manner. Treatment at lower doses and with careful upward titration might be favorable in certain patients with bipolar depression and major depressive disorder in order to minimize the risk of mood switching. Keywords: selective serotonin reuptake inhibitor, SSRI, escitalopram, antidepressant treatment-emergent mania/hypomania, dosage-related, bipolar depressionYamaguchi YKimoto SNagahama TKishimoto TDove Medical PressarticleSelective serotonin reuptake inhibitor (SSRI)escitalopramantidepressant treatment-emergent mania/hypomaniadosage-relatedbipolar depressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2099-2104 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Selective serotonin reuptake inhibitor (SSRI) escitalopram antidepressant treatment-emergent mania/hypomania dosage-related bipolar depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Selective serotonin reuptake inhibitor (SSRI) escitalopram antidepressant treatment-emergent mania/hypomania dosage-related bipolar depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yamaguchi Y Kimoto S Nagahama T Kishimoto T Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
description	Yasunari Yamaguchi, Sohei Kimoto, Takeshi Nagahama, Toshifumi Kishimoto Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan Objective: Several studies have documented that treatment with various antidepressant agents can result in mood switching during major depressive episodes. Escitalopram, one of the newer selective serotonin reuptake inhibitors (SSRIs), is considered preferable due to its relatively high efficacy and acceptability. Although a few cases of escitalopram treatment-emergent mania have been reported, it remains unknown whether this effect is dose-related.Method: In the present report, we discuss three cases of treatment-emergent mania/hypomania in patients receiving escitalopram for major depressive episodes. No patients had a family or personal history of bipolar disorder.Results: In all three cases, manic or hypomanic symptoms emerged within 1 month right after the dosage of escitalopram was increased to 20 mg/day. Moreover, manic episodes subsided as the dosage of escitalopram was reduced. Mood switching was not observed after the cessation of escitalopram treatment.Conclusion: Our case series indicates that escitalopram may induce treatment-emergent mania/hypomania in a dose-related manner. Treatment at lower doses and with careful upward titration might be favorable in certain patients with bipolar depression and major depressive disorder in order to minimize the risk of mood switching. Keywords: selective serotonin reuptake inhibitor, SSRI, escitalopram, antidepressant treatment-emergent mania/hypomania, dosage-related, bipolar depression
format	article
author	Yamaguchi Y Kimoto S Nagahama T Kishimoto T
author_facet	Yamaguchi Y Kimoto S Nagahama T Kishimoto T
author_sort	Yamaguchi Y
title	Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
title_short	Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
title_full	Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
title_fullStr	Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
title_full_unstemmed	Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
title_sort	dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3daa9ae2d03d4d9dbfc1423f34e786a9
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Dosage-related nature of escitalopram treatment-emergent mania/hypomania: a case series

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