A review of the efficacy of mitomycin C in glaucoma filtration surgery

Ahmed Al Habash,1,2 Leyla Ali Aljasim,1 Ohoud Owaidhah,1 Deepak P Edward1,3 1King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia; 3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore,...

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Autores principales:	Al Habash A, Aljasim LA, Owaidhah O, Edward DP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/3dab14a935fe4d5895e57febc8d9b5ec
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spelling	oai:doaj.org-article:3dab14a935fe4d5895e57febc8d9b5ec2021-12-02T00:48:22ZA review of the efficacy of mitomycin C in glaucoma filtration surgery1177-5483https://doaj.org/article/3dab14a935fe4d5895e57febc8d9b5ec2015-10-01T00:00:00Zhttps://www.dovepress.com/a-review-of-the-efficacy-of-mitomycin-c-in-glaucoma-filtration-surgery-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ahmed Al Habash,1,2 Leyla Ali Aljasim,1 Ohoud Owaidhah,1 Deepak P Edward1,3 1King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia; 3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The success of trabeculectomy, which is considered the gold standard in the surgical treatment of glaucoma, depends on the wound healing response. The introduction of antiproliferative agents such as mitomycin C (MMC) has increased the success rates of trabeculectomy. However, complications due to these agents can be challenging to manage. Hence, it is important to determine the most efficacious dose and duration of exposure. Multiple studies suggest that many factors, including but not limited to MMC preparation, different concentrations, different exposure times, and method of application may affect success rate, and these factors were reviewed in this article. We concluded that lower concentrations of MMC that are prepared and applied in a standardized fashion, such as that using the Mitosol® kit (for 2–3 minutes) during trabeculectomy, could potentially provide trabeculectomy success rates similar to that reported with off-label preparations, and that such a treatment regime could result in in lower complication rates than higher doses of MMC. Keywords: mitomycin C, Mitosol, filtering surgery, trabeculectomy, outcomesAl Habash AAljasim LAOwaidhah OEdward DPDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1945-1951 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Al Habash A Aljasim LA Owaidhah O Edward DP A review of the efficacy of mitomycin C in glaucoma filtration surgery
description	Ahmed Al Habash,1,2 Leyla Ali Aljasim,1 Ohoud Owaidhah,1 Deepak P Edward1,3 1King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia; 3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The success of trabeculectomy, which is considered the gold standard in the surgical treatment of glaucoma, depends on the wound healing response. The introduction of antiproliferative agents such as mitomycin C (MMC) has increased the success rates of trabeculectomy. However, complications due to these agents can be challenging to manage. Hence, it is important to determine the most efficacious dose and duration of exposure. Multiple studies suggest that many factors, including but not limited to MMC preparation, different concentrations, different exposure times, and method of application may affect success rate, and these factors were reviewed in this article. We concluded that lower concentrations of MMC that are prepared and applied in a standardized fashion, such as that using the Mitosol® kit (for 2–3 minutes) during trabeculectomy, could potentially provide trabeculectomy success rates similar to that reported with off-label preparations, and that such a treatment regime could result in in lower complication rates than higher doses of MMC. Keywords: mitomycin C, Mitosol, filtering surgery, trabeculectomy, outcomes
format	article
author	Al Habash A Aljasim LA Owaidhah O Edward DP
author_facet	Al Habash A Aljasim LA Owaidhah O Edward DP
author_sort	Al Habash A
title	A review of the efficacy of mitomycin C in glaucoma filtration surgery
title_short	A review of the efficacy of mitomycin C in glaucoma filtration surgery
title_full	A review of the efficacy of mitomycin C in glaucoma filtration surgery
title_fullStr	A review of the efficacy of mitomycin C in glaucoma filtration surgery
title_full_unstemmed	A review of the efficacy of mitomycin C in glaucoma filtration surgery
title_sort	review of the efficacy of mitomycin c in glaucoma filtration surgery
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3dab14a935fe4d5895e57febc8d9b5ec
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A review of the efficacy of mitomycin C in glaucoma filtration surgery

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