Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception

Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception

Haiyan Wang1 ,* Yu Zhang1 ,* Xiaqing Ma,1 Wenying Wang,1 Xiaotao Xu,1 Min Huang,1 Liang Xu,2 Haibo Shi,3 Tifei Yuan,4 Wei Jiang,1 Aizhong Wang,1 Tao Xu1,5 1Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Re...

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Bibliographic Details
Main Authors: Wang H, Zhang Y, Ma X, Wang W, Xu X, Huang M, Xu L, Shi H, Yuan T, Jiang W, Wang A, Xu T
Format: article
Language:EN
Published: Dove Medical Press 2020
Subjects:
morphine
tolerance
nlrp3
tlr4
p2x7r
neuroinflammation
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/3dabec13168944d39c65da867de8db8b
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