Role of network-mediated stochasticity in mammalian drug resistance

The role of gene expression noise in the evolution of drug resistance in mammalian cells is unclear. Here, by uncoupling noise from mean expression of a drug resistance gene in CHO cells the authors show that noisy expression aids adaptation to high drug levels, but delays it at low drug levels.

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Autores principales:	Kevin S. Farquhar, Daniel A. Charlebois, Mariola Szenk, Joseph Cohen, Dmitry Nevozhay, Gábor Balázsi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dae225529974c6a8456ae2ac990839b
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spelling	oai:doaj.org-article:3dae225529974c6a8456ae2ac990839b2021-12-02T16:57:51ZRole of network-mediated stochasticity in mammalian drug resistance10.1038/s41467-019-10330-w2041-1723https://doaj.org/article/3dae225529974c6a8456ae2ac990839b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10330-whttps://doaj.org/toc/2041-1723The role of gene expression noise in the evolution of drug resistance in mammalian cells is unclear. Here, by uncoupling noise from mean expression of a drug resistance gene in CHO cells the authors show that noisy expression aids adaptation to high drug levels, but delays it at low drug levels.Kevin S. FarquharDaniel A. CharleboisMariola SzenkJoseph CohenDmitry NevozhayGábor BalázsiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin S. Farquhar Daniel A. Charlebois Mariola Szenk Joseph Cohen Dmitry Nevozhay Gábor Balázsi Role of network-mediated stochasticity in mammalian drug resistance
description	The role of gene expression noise in the evolution of drug resistance in mammalian cells is unclear. Here, by uncoupling noise from mean expression of a drug resistance gene in CHO cells the authors show that noisy expression aids adaptation to high drug levels, but delays it at low drug levels.
format	article
author	Kevin S. Farquhar Daniel A. Charlebois Mariola Szenk Joseph Cohen Dmitry Nevozhay Gábor Balázsi
author_facet	Kevin S. Farquhar Daniel A. Charlebois Mariola Szenk Joseph Cohen Dmitry Nevozhay Gábor Balázsi
author_sort	Kevin S. Farquhar
title	Role of network-mediated stochasticity in mammalian drug resistance
title_short	Role of network-mediated stochasticity in mammalian drug resistance
title_full	Role of network-mediated stochasticity in mammalian drug resistance
title_fullStr	Role of network-mediated stochasticity in mammalian drug resistance
title_full_unstemmed	Role of network-mediated stochasticity in mammalian drug resistance
title_sort	role of network-mediated stochasticity in mammalian drug resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3dae225529974c6a8456ae2ac990839b
work_keys_str_mv	AT kevinsfarquhar roleofnetworkmediatedstochasticityinmammaliandrugresistance AT danielacharlebois roleofnetworkmediatedstochasticityinmammaliandrugresistance AT mariolaszenk roleofnetworkmediatedstochasticityinmammaliandrugresistance AT josephcohen roleofnetworkmediatedstochasticityinmammaliandrugresistance AT dmitrynevozhay roleofnetworkmediatedstochasticityinmammaliandrugresistance AT gaborbalazsi roleofnetworkmediatedstochasticityinmammaliandrugresistance
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Role of network-mediated stochasticity in mammalian drug resistance

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