The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:3daed719cc8f4fb3a0c84168a894c7e5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:3daed719cc8f4fb3a0c84168a894c7e52021-12-02T11:56:18ZThe ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation10.1038/s41467-020-20208-x2041-1723https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20208-xhttps://doaj.org/toc/2041-1723Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence.Guangjian FanLianhui SunLing MengChen HuXing WangZhan ShiCongli HuYang HanQingqing YangLiu CaoXiaohong ZhangYan ZhangXianmin SongShujie XiaBaokun HeShengping ZhangChuangui WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Guangjian Fan Lianhui Sun Ling Meng Chen Hu Xing Wang Zhan Shi Congli Hu Yang Han Qingqing Yang Liu Cao Xiaohong Zhang Yan Zhang Xianmin Song Shujie Xia Baokun He Shengping Zhang Chuangui Wang The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| description |
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence. |
| format |
article |
| author |
Guangjian Fan Lianhui Sun Ling Meng Chen Hu Xing Wang Zhan Shi Congli Hu Yang Han Qingqing Yang Liu Cao Xiaohong Zhang Yan Zhang Xianmin Song Shujie Xia Baokun He Shengping Zhang Chuangui Wang |
| author_facet |
Guangjian Fan Lianhui Sun Ling Meng Chen Hu Xing Wang Zhan Shi Congli Hu Yang Han Qingqing Yang Liu Cao Xiaohong Zhang Yan Zhang Xianmin Song Shujie Xia Baokun He Shengping Zhang Chuangui Wang |
| author_sort |
Guangjian Fan |
| title |
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| title_short |
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| title_full |
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| title_fullStr |
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| title_full_unstemmed |
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation |
| title_sort |
atm and atr kinases regulate centrosome clustering and tumor recurrence by targeting kifc1 phosphorylation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e5 |
| work_keys_str_mv |
AT guangjianfan theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT lianhuisun theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT lingmeng theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT chenhu theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xingwang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT zhanshi theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT conglihu theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT yanghan theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT qingqingyang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT liucao theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xiaohongzhang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT yanzhang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xianminsong theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT shujiexia theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT baokunhe theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT shengpingzhang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT chuanguiwang theatmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT guangjianfan atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT lianhuisun atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT lingmeng atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT chenhu atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xingwang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT zhanshi atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT conglihu atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT yanghan atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT qingqingyang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT liucao atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xiaohongzhang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT yanzhang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT xianminsong atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT shujiexia atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT baokunhe atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT shengpingzhang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation AT chuanguiwang atmandatrkinasesregulatecentrosomeclusteringandtumorrecurrencebytargetingkifc1phosphorylation |
| _version_ |
1718394801045372928 |