The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation

Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence.

Guardado en:
Detalles Bibliográficos
Autores principales: Guangjian Fan, Lianhui Sun, Ling Meng, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang, Chuangui Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares