Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin and phenotype of inflammatory IL-11+ fibroblasts i...

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Autores principales: Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3db3ac661ebb40e88567f28d3824a2f8
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spelling oai:doaj.org-article:3db3ac661ebb40e88567f28d3824a2f82021-12-02T18:03:13ZInterleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer10.1038/s41467-021-22450-32041-1723https://doaj.org/article/3db3ac661ebb40e88567f28d3824a2f82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22450-3https://doaj.org/toc/2041-1723The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin and phenotype of inflammatory IL-11+ fibroblasts in colitis and colon cancer preclinical models.Takashi NishinaYutaka DeguchiDaisuke OhshimaWakami TakedaMasato OhtsukaShigeyuki ShichinoSatoshi UehaSoh YamazakiMika KawauchiEri NakamuraChiharu NishiyamaYuko KojimaSatomi Adachi-AkahaneMizuho HasegawaMizuho NakayamaMasanobu OshimaHideo YagitaKazutoshi ShibuyaTetuo MikamiNaohiro InoharaKouji MatsushimaNorihiro TadaHiroyasu NakanoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takashi Nishina
Yutaka Deguchi
Daisuke Ohshima
Wakami Takeda
Masato Ohtsuka
Shigeyuki Shichino
Satoshi Ueha
Soh Yamazaki
Mika Kawauchi
Eri Nakamura
Chiharu Nishiyama
Yuko Kojima
Satomi Adachi-Akahane
Mizuho Hasegawa
Mizuho Nakayama
Masanobu Oshima
Hideo Yagita
Kazutoshi Shibuya
Tetuo Mikami
Naohiro Inohara
Kouji Matsushima
Norihiro Tada
Hiroyasu Nakano
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
description The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin and phenotype of inflammatory IL-11+ fibroblasts in colitis and colon cancer preclinical models.
format article
author Takashi Nishina
Yutaka Deguchi
Daisuke Ohshima
Wakami Takeda
Masato Ohtsuka
Shigeyuki Shichino
Satoshi Ueha
Soh Yamazaki
Mika Kawauchi
Eri Nakamura
Chiharu Nishiyama
Yuko Kojima
Satomi Adachi-Akahane
Mizuho Hasegawa
Mizuho Nakayama
Masanobu Oshima
Hideo Yagita
Kazutoshi Shibuya
Tetuo Mikami
Naohiro Inohara
Kouji Matsushima
Norihiro Tada
Hiroyasu Nakano
author_facet Takashi Nishina
Yutaka Deguchi
Daisuke Ohshima
Wakami Takeda
Masato Ohtsuka
Shigeyuki Shichino
Satoshi Ueha
Soh Yamazaki
Mika Kawauchi
Eri Nakamura
Chiharu Nishiyama
Yuko Kojima
Satomi Adachi-Akahane
Mizuho Hasegawa
Mizuho Nakayama
Masanobu Oshima
Hideo Yagita
Kazutoshi Shibuya
Tetuo Mikami
Naohiro Inohara
Kouji Matsushima
Norihiro Tada
Hiroyasu Nakano
author_sort Takashi Nishina
title Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
title_short Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
title_full Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
title_fullStr Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
title_full_unstemmed Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
title_sort interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3db3ac661ebb40e88567f28d3824a2f8
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