Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and showing that MC1 represents novel class of RabGE...

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Autores principales:	Stephan Kiontke, Lars Langemeyer, Anne Kuhlee, Saskia Schuback, Stefan Raunser, Christian Ungermann, Daniel Kümmel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3db419966f5f44748a3a872c39345aec
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spelling	oai:doaj.org-article:3db419966f5f44748a3a872c39345aec2021-12-02T15:39:00ZArchitecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz110.1038/ncomms140342041-1723https://doaj.org/article/3db419966f5f44748a3a872c39345aec2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14034https://doaj.org/toc/2041-1723The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and showing that MC1 represents novel class of RabGEFs.Stephan KiontkeLars LangemeyerAnne KuhleeSaskia SchubackStefan RaunserChristian UngermannDaniel KümmelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Kiontke Lars Langemeyer Anne Kuhlee Saskia Schuback Stefan Raunser Christian Ungermann Daniel Kümmel Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
description	The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and showing that MC1 represents novel class of RabGEFs.
format	article
author	Stephan Kiontke Lars Langemeyer Anne Kuhlee Saskia Schuback Stefan Raunser Christian Ungermann Daniel Kümmel
author_facet	Stephan Kiontke Lars Langemeyer Anne Kuhlee Saskia Schuback Stefan Raunser Christian Ungermann Daniel Kümmel
author_sort	Stephan Kiontke
title	Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
title_short	Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
title_full	Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
title_fullStr	Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
title_full_unstemmed	Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1
title_sort	architecture and mechanism of the late endosomal rab7-like ypt7 guanine nucleotide exchange factor complex mon1–ccz1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3db419966f5f44748a3a872c39345aec
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Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

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