Sustained release from a metal - Analgesics entrapped within biocidal silver

Abstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release o...

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Autores principales:	Barak Menagen, Rami Pedahzur, David Avnir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3db453190e7b4901b6cbdff003104939
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spelling	oai:doaj.org-article:3db453190e7b4901b6cbdff0031049392021-12-02T11:52:31ZSustained release from a metal - Analgesics entrapped within biocidal silver10.1038/s41598-017-03195-w2045-2322https://doaj.org/article/3db453190e7b4901b6cbdff0031049392017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03195-whttps://doaj.org/toc/2045-2322Abstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release. The metal in our case acts not only as a drug releasing source, but also as an antibacterial agent and this property of the composites was studied. Unexpectedly, it was found that the entrapment of the analgesics within silver, dramatically enhances the growth inhibition activity of wild type Pseudomonas aeruginosa, exceeding by far the inhibition activity of the separate components. A mechanism for this interesting observation is provided. The strong antimicrobial activity combined with the analgesic activity open the road for future applications of these materials as dual-purpose components in wound treatment.Barak MenagenRami PedahzurDavid AvnirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barak Menagen Rami Pedahzur David Avnir Sustained release from a metal - Analgesics entrapped within biocidal silver
description	Abstract Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release. The metal in our case acts not only as a drug releasing source, but also as an antibacterial agent and this property of the composites was studied. Unexpectedly, it was found that the entrapment of the analgesics within silver, dramatically enhances the growth inhibition activity of wild type Pseudomonas aeruginosa, exceeding by far the inhibition activity of the separate components. A mechanism for this interesting observation is provided. The strong antimicrobial activity combined with the analgesic activity open the road for future applications of these materials as dual-purpose components in wound treatment.
format	article
author	Barak Menagen Rami Pedahzur David Avnir
author_facet	Barak Menagen Rami Pedahzur David Avnir
author_sort	Barak Menagen
title	Sustained release from a metal - Analgesics entrapped within biocidal silver
title_short	Sustained release from a metal - Analgesics entrapped within biocidal silver
title_full	Sustained release from a metal - Analgesics entrapped within biocidal silver
title_fullStr	Sustained release from a metal - Analgesics entrapped within biocidal silver
title_full_unstemmed	Sustained release from a metal - Analgesics entrapped within biocidal silver
title_sort	sustained release from a metal - analgesics entrapped within biocidal silver
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3db453190e7b4901b6cbdff003104939
work_keys_str_mv	AT barakmenagen sustainedreleasefromametalanalgesicsentrappedwithinbiocidalsilver AT ramipedahzur sustainedreleasefromametalanalgesicsentrappedwithinbiocidalsilver AT davidavnir sustainedreleasefromametalanalgesicsentrappedwithinbiocidalsilver
_version_	1718394979048488960

Sustained release from a metal - Analgesics entrapped within biocidal silver

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