ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY
Early course of acute systemic inflammatory response after surgical intervention was traced for sixty-four patients with chronic calculous cholecystitis following a laparoscopic cholecystectomy (LCE). The patients were classified in 2 groups dependent on the surgery mode. The main group included 32...
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oai:doaj.org-article:3db5f8a6b13e489595a102011c55dc4f2021-11-18T08:03:45ZACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY1563-06252313-741X10.15789/1563-0625-2015-6-561-566https://doaj.org/article/3db5f8a6b13e489595a102011c55dc4f2016-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/963https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEarly course of acute systemic inflammatory response after surgical intervention was traced for sixty-four patients with chronic calculous cholecystitis following a laparoscopic cholecystectomy (LCE). The patients were classified in 2 groups dependent on the surgery mode. The main group included 32 patients after single-port LCE, and controls that underwent four-port LCE (n = 32). Peripheral blood samples were taken 2 h before intervention, as well as 6, 24, and 48 h after surgical treatment. of Alpha-1-antitrypsin (A1AT), C-reactive protein, TNFα and IL-1β levels were measured in the specimens. For A1AT, we have not found any significant differences between the baseline and post-surgery levels, both in main and control groups. The intergroup comparisons showed a statistically significant increase in A1AT levels 24 h after the 4-port LCE. The patients subjected to single-port LCE, exhibited similar pre- and post-surgery levels of C-reactive protein. In the control group, its level proved to be statistically higher against initial values 6 h after the surgery. Comparing the both groups, C-reactive protein was found to be significantly increased in controls 6 и 24 h after surgery.The post-op TNFα levels after the single-port LCE tended to increase, as compared to the baseline values. A statistical increase of TNF levels over initial values was noted 24 h after the 4-port LCE. Upon the intergroup comparisons, a significant TNF increase was revealed 24 following the 4-port LCE. IL-1β levels in the main group did not differ between the pre- and post-surgical period. However, its statistically significant increase to the initial values was revealed in controls 24 h after surgery. A comparison for IL-1β levels between the 2 groups has shown its significant elevation 24 h after the 4-port LCE. These data allow to conclude that a systemic inflammatory response as assessed by acute phase proteins in patients after a single-port LCE, is characterized by a shorter and less marked inflammatory reaction, as compared to the reaction in patients after the 4-port LCE.A. V. AlekberzadeE. M. LypnitskiyJ. A. BadalovSPb RAACIarticlelaparoscopycholecystectomyα-1-antitrypsincrptnfαil-1βImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 6, Pp 561-566 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
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RU |
| topic |
laparoscopy cholecystectomy α-1-antitrypsin crp tnfα il-1β Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
laparoscopy cholecystectomy α-1-antitrypsin crp tnfα il-1β Immunologic diseases. Allergy RC581-607 A. V. Alekberzade E. M. Lypnitskiy J. A. Badalov ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| description |
Early course of acute systemic inflammatory response after surgical intervention was traced for sixty-four patients with chronic calculous cholecystitis following a laparoscopic cholecystectomy (LCE). The patients were classified in 2 groups dependent on the surgery mode. The main group included 32 patients after single-port LCE, and controls that underwent four-port LCE (n = 32). Peripheral blood samples were taken 2 h before intervention, as well as 6, 24, and 48 h after surgical treatment. of Alpha-1-antitrypsin (A1AT), C-reactive protein, TNFα and IL-1β levels were measured in the specimens. For A1AT, we have not found any significant differences between the baseline and post-surgery levels, both in main and control groups. The intergroup comparisons showed a statistically significant increase in A1AT levels 24 h after the 4-port LCE. The patients subjected to single-port LCE, exhibited similar pre- and post-surgery levels of C-reactive protein. In the control group, its level proved to be statistically higher against initial values 6 h after the surgery. Comparing the both groups, C-reactive protein was found to be significantly increased in controls 6 и 24 h after surgery.The post-op TNFα levels after the single-port LCE tended to increase, as compared to the baseline values. A statistical increase of TNF levels over initial values was noted 24 h after the 4-port LCE. Upon the intergroup comparisons, a significant TNF increase was revealed 24 following the 4-port LCE. IL-1β levels in the main group did not differ between the pre- and post-surgical period. However, its statistically significant increase to the initial values was revealed in controls 24 h after surgery. A comparison for IL-1β levels between the 2 groups has shown its significant elevation 24 h after the 4-port LCE. These data allow to conclude that a systemic inflammatory response as assessed by acute phase proteins in patients after a single-port LCE, is characterized by a shorter and less marked inflammatory reaction, as compared to the reaction in patients after the 4-port LCE. |
| format |
article |
| author |
A. V. Alekberzade E. M. Lypnitskiy J. A. Badalov |
| author_facet |
A. V. Alekberzade E. M. Lypnitskiy J. A. Badalov |
| author_sort |
A. V. Alekberzade |
| title |
ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| title_short |
ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| title_full |
ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| title_fullStr |
ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| title_full_unstemmed |
ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY |
| title_sort |
acute phase of systemic inflammatory response following a single-port laparoscopic cholecystectomy |
| publisher |
SPb RAACI |
| publishDate |
2016 |
| url |
https://doaj.org/article/3db5f8a6b13e489595a102011c55dc4f |
| work_keys_str_mv |
AT avalekberzade acutephaseofsystemicinflammatoryresponsefollowingasingleportlaparoscopiccholecystectomy AT emlypnitskiy acutephaseofsystemicinflammatoryresponsefollowingasingleportlaparoscopiccholecystectomy AT jabadalov acutephaseofsystemicinflammatoryresponsefollowingasingleportlaparoscopiccholecystectomy |
| _version_ |
1718422411550916608 |