Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane

Human YME1L is a membrane-anchored AAA+ protease that maintains proteostasis in the mitochondrial inner membrane and intermembrane space. Here the authors probe the substrate-binding and degradation activities of YME1L and suggest the existence of sequence-specific degradation signals in mitochondri...

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Autores principales:	Hui Shi, Anthony J. Rampello, Steven E. Glynn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3db827aef2cf4801aba354af3ff93103
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spelling	oai:doaj.org-article:3db827aef2cf4801aba354af3ff931032021-12-02T17:33:20ZEngineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane10.1038/ncomms133012041-1723https://doaj.org/article/3db827aef2cf4801aba354af3ff931032016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13301https://doaj.org/toc/2041-1723Human YME1L is a membrane-anchored AAA+ protease that maintains proteostasis in the mitochondrial inner membrane and intermembrane space. Here the authors probe the substrate-binding and degradation activities of YME1L and suggest the existence of sequence-specific degradation signals in mitochondrial proteostasis.Hui ShiAnthony J. RampelloSteven E. GlynnNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Shi Anthony J. Rampello Steven E. Glynn Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
description	Human YME1L is a membrane-anchored AAA+ protease that maintains proteostasis in the mitochondrial inner membrane and intermembrane space. Here the authors probe the substrate-binding and degradation activities of YME1L and suggest the existence of sequence-specific degradation signals in mitochondrial proteostasis.
format	article
author	Hui Shi Anthony J. Rampello Steven E. Glynn
author_facet	Hui Shi Anthony J. Rampello Steven E. Glynn
author_sort	Hui Shi
title	Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
title_short	Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
title_full	Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
title_fullStr	Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
title_full_unstemmed	Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
title_sort	engineered aaa+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3db827aef2cf4801aba354af3ff93103
work_keys_str_mv	AT huishi engineeredaaaproteasesrevealprinciplesofproteolysisatthemitochondrialinnermembrane AT anthonyjrampello engineeredaaaproteasesrevealprinciplesofproteolysisatthemitochondrialinnermembrane AT steveneglynn engineeredaaaproteasesrevealprinciplesofproteolysisatthemitochondrialinnermembrane
_version_	1718379994367918080

Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane

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