Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

Inflammatory response to malaria pathogen Plasmodium falciparumcan be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.

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Detalles Bibliográficos
Autores principales: Pierre-Yves Mantel, Daisy Hjelmqvist, Michael Walch, Solange Kharoubi-Hess, Sandra Nilsson, Deepali Ravel, Marina Ribeiro, Christof Grüring, Siyuan Ma, Prasad Padmanabhan, Alexander Trachtenberg, Johan Ankarklev, Nicolas M. Brancucci, Curtis Huttenhower, Manoj T. Duraisingh, Ionita Ghiran, Winston P. Kuo, Luis Filgueira, Roberta Martinelli, Matthias Marti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/3dbc56a1b2a84b54b49094d3638bdf38
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Descripción
Sumario:Inflammatory response to malaria pathogen Plasmodium falciparumcan be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.

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